Improving Response Rates to EGFR-Targeted Therapies for Head and Neck Squamous Cell Carcinoma: Candidate Predictive Biomarkers and Combination Treatment with Src Inhibitors

Table 1

EGFR-targeted therapies in clinical development for SCCHN.

Agent		Sponsor	Class	FDA-approval	Clinical trial phase for SCCHN
Antibodies
Cetuximab	C225, Erbitux	ImClone Systems	Chimeric IgG1	SCCHN; colorectal cancers	III
Nimotuzumab	h-R3	YM Biosciences	Humanized IgG1	—	IV Advanced disease; II Locally advanced disease
Panitumumab	ABX-EGF; Vectibix	Amgen	Fully human IgG2	Colorectal cancers	III
Zalutumumab	HuMax-EGFR	GenMab	Fully human IgG1	—	III
Tyrosine kinase inhibitors
Erlotinib	Tarceva; OSI-774	Genetech and OSI Pharmaceuticals	Reversible ATP competive	Lung cancer	III
Gefitinib	ZD-1839; Iressa	AstraZeneca	Reversible ATP competive	Lung cancer, relabeling limits	III
Lapatinib	Tykerb	GlaxoSmithKline	Reversible ATP competitive dual EGFR/Her2	Breast cancer	III
Zactima	ZD6474	AstraZeneca	Reversible ATP competitive VEGFR-2, EGFR and RET	—	II