Precursor Lesions of High-Grade Serous Ovarian Carcinoma: Morphological and Molecular Characteristics
Figure 1
Serous tubal intraepithelial carcinoma (STIC). (a) The morphological features of a small STIC showing papillary architecture with intraepithelial carcinoma cells, many of which are detached and are able to freely disseminate onto ovaries, pelvic, or peritoneal wall. (b) The p53 immunohistochemistry demonstrates that all intraepithelial carcinoma cells are intensely positive for p53 nuclear immunoreactivity. In contrast, the normal-appearing tubal epithelial cells flanking the STIC are negative for p53.
