Potential target sites for Eph receptor/ephrin-associated antiangiogenic therapy. The illustrated strategies for intracellular inhibition of forward signaling via kinase inhibitors and gene silencing, respectively, also could be applied for reverse signaling. PDZ: Post synaptic density 95-Discs large-Zonula occludentes-1-protein, siRNA: small interfering RNA, AS-ODN: antisense oligodeoxynucleotides, Rho: Rho-GTPase Src: Src kinase, Akt: Akt kinase, MAPK: mitogen-activated protein kinase.