The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

Figure 5

The decrease of PR in the 2-week-old Pten^d/dK-ras^G12D mice. (a) Western blot analysis of PTEN, AKT, phosphor-AKT, ERα , and PR in 2 week old control, K-ras^G12D, Pten^d/d, and Pten^d/dK-ras^G12D mice. (b)-(c) Immunohistochemical analysis of ERα (b) and PR (c) in uteri of control, K-ras^G12D, Pten^d/d, and Pten^d/dK-ras^G12D mice. Immunohistochemical analysis of PR shows that it is decreased in the Pten^d/dK-ras^G12D uteri compared to other mice. Scale bar: 100 𝜇m.

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