The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

Figure 6

The increase of ER𝛼 signaling in the 2-week-old Pten^d/dK-ras^G12D mice. Real-time RT-PCR analysis of Ltf, Clca3, and C3 was performed in uteri of control, K-ras^G12D, Pten^d/d, and Pten^d/dK-ras^G12D mice at 2 weeks of age. The results represent the mean ± SEM of three independent RNA sets. ^***, 𝑃<.001, one-way ANOVA followed by Tukey’s post hoc multiple range test.

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