Cognitive Sparing during the Administration of Whole Brain Radiotherapy and Prophylactic Cranial Irradiation: Current Concepts and Approaches
Table 3
NCI Common Toxicity Criteria Version 2.0 Summary.
Grade 0
Normal
Grade 1
Confusion/disorientation which resolves without sequelae, somnolence/dizziness/extrapyramidal symptoms/insomnia/memory loss/mood alterations/neuropathy/personality changes/pyramidal symptoms/tremor/vertigo not interfering with daily function, mild atrophy or limited T2 hyperintensities on MRI (1/3 of cerebrum), nystagmus
Grade 2
Persistent confusion/disorientation/poor attention span not interfering with daily function, somnolence/dizziness/extrapyramidal symptoms/insomnia/memory loss/mood alterations/neuropathy/personality changes/pyramidal symptoms/tremor/vertigo/cranial neuropathies not interfering with activities of daily living (ADL), moderate atrophy or more extensive T2 hyperintensities on MRI (1/3-2/3 of cerebrum) extending into centrum ovale, nystagmus
Grade 3
Delusions, hallucinations, syncope, severe atrophy or near total T2 hyperintensities on MRI / focal white matter necrosis, persistent confusion/disorientation/poor attention span/somnolence/dizziness/extrapyramidal symptoms/insomnia/memory loss/mood alterations/neuropathy/personality changes/pyramidal symptoms/tremor/vertigo/cranial neuropathies interfering with activities of daily living (ADL)
Grade 4
Bedridden/disabled due to brain toxicity, requiring hospitalization doe to risk to self/others, psychotic, unable to communicate, amnesia, diffuse calcification or necrosis, paralysis
