- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Journal of Oncology
Volume 2010 (2010), Article ID 232831, 10 pages
Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells
1Department of Urology, Emory School of Medicine, Atlanta, GA 30311, USA
2Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
3Department of Biology and Center for Cancer Research, Tuskegee University, Carver Research Foundation, Tuskegee, AL 36088, USA
4Department of Radiation Oncology, Emory School of Medicine, Atlanta, GA 30322, USA
5Department of Biology, Georgia State University, Atlanta, GA 30303, USA
Received 15 March 2010; Revised 12 May 2010; Accepted 12 May 2010
Academic Editor: Claudia D. Andl
Copyright © 2010 Sajni Josson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. F. Chambers, A. C. Groom, and I. C. MacDonald, “Dissemination and growth of cancer cells in metastatic sites,” Nature Reviews Cancer, vol. 2, no. 8, pp. 563–572, 2002.
- P. M. Comoglio and L. Trusolino, “Invasive growth: from development to metastasis,” Journal of Clinical Investigation, vol. 109, no. 7, pp. 857–862, 2002.
- J. M. Veltmaat, C. C. Orelio, D. Ward-Van Oostwaard, M. A. Van Rooijen, C. L. Mummery, and L. H. K. Defize, “Snail is an immediate early target gene of parathyroid hormone related peptide signaling in parietal endoderm formation,” The International Journal of Developmental Biology, vol. 44, no. 3, pp. 297–307, 2000.
- B. Ciruna and J. Rossant, “FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak,” Developmental Cell, vol. 1, no. 1, pp. 37–49, 2001.
- J. C. Machado, C. Oliveira, R. Carvalho et al., “E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma,” Oncogene, vol. 20, no. 12, pp. 1525–1528, 2001.
- J. P. Thiery, “Epithelial-mesenchymal transitions in tumor progression,” Nature Reviews Cancer, vol. 2, no. 6, pp. 442–454, 2002.
- R. C. Bates and A. M. Mercurio, “The epithelial-mesenchymal transition (EMT) and colorectal cancer progression,” Cancer Biology and Therapy, vol. 4, no. 4, pp. 365–370, 2005.
- T. Brabletz, A. Jung, S. Reu et al., “Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 18, pp. 10356–10361, 2001.
- I. Poser, D. Domínguez, A. G. de Herreros, A. Varnai, R. Buettner, and A. K. Bosserhoff, “Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail,” The Journal of Biological Chemistry, vol. 276, no. 27, pp. 24661–24666, 2001.
- A. M. Lowy, J. Knight, and J. Groden, “Restoration of E-cadherin/β-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis,” Surgery, vol. 132, no. 2, pp. 141–148, 2002.
- G. Strathdee, “Epigenetic versus genetic alterations in the inactivation of E-cadherin,” Seminars in Cancer Biology, vol. 12, no. 5, pp. 373–379, 2002.
- C. Yates, C. R. Shepard, G. Papworth et al., “Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression,” Advances in Cancer Research, vol. 97, pp. 225–246, 2007.
- C. C. Yates, C. R. Shepard, D. B. Stolz, and A. Wells, “Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin,” British Journal of Cancer, vol. 96, no. 8, pp. 1246–1252, 2007.
- B. Saha, B. Chaiwun, S. S. Imam et al., “Overexpression of E-cadherin protein in metastatic breast cancer cells in bone,” Anticancer Research, vol. 27, no. 6 B, pp. 3903–3908, 2007.
- H. S. Oh, A. Moharita, J. G. Potian et al., “Bone marrow stroma influences transforming growth factor-β production in breast cancer cells to regulate c-myc activation of the preprotachykinin-I gene in breast cancer cells,” Cancer Research, vol. 64, no. 17, pp. 6327–6336, 2004.
- N. A. Bhowmick and H. L. Moses, “Tumor-stroma interactions,” Current Opinion in Genetics and Development, vol. 15, no. 1, pp. 97–101, 2005.
- M. L. Ackland, D. F. Newgreen, M. Fridman et al., “Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells,” Laboratory Investigation, vol. 83, no. 3, pp. 435–448, 2003.
- C. D. Andl, T. Mizushima, H. Nakagawa et al., “Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo,” The Journal of Biological Chemistry, vol. 278, no. 3, pp. 1824–1830, 2003.
- A. P. Armstrong, R. E. Miller, J. C. Jones, J. Zhang, E. T. Keller, and W. C. Dougall, “RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes,” Prostate, vol. 68, no. 1, pp. 92–104, 2008.
- V. A. Odero-Marah, R. Wang, G. Chu et al., “Receptor activator of NF-κB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells,” Cell Research, vol. 18, no. 8, pp. 858–870, 2008.
- M. D. Mason, G. Davies, and W. G. Jiang, “Cell adhesion molecules and adhesion abnormalities in prostate cancer,” Critical Reviews in Oncology/Hematology, vol. 41, no. 1, pp. 11–28, 2002.
- X. Qian, T. Karpova, A. M. Sheppard, J. McNally, and D. R. Lowy, “E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases,” The EMBO Journal, vol. 23, no. 8, pp. 1739–1748, 2004.
- S. K. Green, M. C. I. Karlsson, J. V. Ravetch, and R. S. Kerbel, “Disruption of cell-cell adhesion enhances antibody-dependent cellular cytotoxicity: implications for antibody-based therapeutics of cancer,” Cancer Research, vol. 62, no. 23, pp. 6891–6900, 2002.
- H. E. Zhau, C.-L. Li, and L. W. K. Chung, “Establishment of human prostate carcinoma skeletal metastasis models,” Cancer, vol. 88, no. 12, pp. 2995–3001, 2000.
- J. Xu, R. Wang, Z. H. Xie et al., “Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis,” Prostate, vol. 66, no. 15, pp. 1664–1673, 2006.
- H. He, X. Yang, A. J. Davidson et al., “Progressive epithelial to mesenchymal transitions in prostate cancer cells during xenograft tumor formation and metastasis,” Prostate, vol. 70, no. 5, pp. 518–528, 2010.
- H. E. Zhau, V. Odero-Marah, H.-W. Lue et al., “Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model,” Clinical & Experimental Metastasis, vol. 25, no. 6, pp. 601–610, 2008.
- A. Wells, C. Yates, and C. R. Shepard, “E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas,” Clinical & Experimental Metastasis, vol. 25, no. 6, pp. 621–628, 2008.
- B. Saha, P. Kaur, D. Tsao-Wei et al., “Unmethylated E-cadherin gene expressionis significantly associated with metastatic human prostate cancer cells in bone,” Prostate, vol. 68, no. 15, pp. 1681–1688, 2008.
- L.-N. Li, H.-D. Zhang, S.-J. Yuan, D.-X. Yang, L. Wang, and Z.-X. Sun, “Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin,” European Journal of Pharmacology, vol. 588, no. 1, pp. 1–8, 2008.
- S.-Y. Sung, C.-L. Hsieh, A. Law et al., “Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis,” Cancer Research, vol. 68, no. 23, pp. 9996–10003, 2008.
- A. R. Howlett, N. Bailey, C. Damsky, O. W. Petersen, and M. J. Bissell, “Cellular growth and survival are mediated by β1 integrins in normal human breast eqithelium but not in breast carcinoma,” Journal of Cell Science, vol. 108, no. 5, pp. 1945–1957, 1995.
- M. Fornaro, J. Plescia, S. Chheang et al., “Fibronectin protects prostate cancer cells from tumor necrosis factor-α-induced apoptosis via the AKT/survivin pathway,” The Journal of Biological Chemistry, vol. 278, no. 50, pp. 50402–50411, 2003.
- G. Li, K. Satyamoorthy, and M. Herlyn, “N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells,” Cancer Research, vol. 61, no. 9, pp. 3819–3825, 2001.
- K. Bisanz, J. Yu, M. Edlund et al., “Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model,” Molecular Therapy, vol. 12, no. 4, pp. 634–643, 2005.
- M. A. Rubin, N. R. Mucci, J. Figurski, A. Fecko, K. J. Pienta, and M. L. Day, “E-cadherin expression in prostate cancer: a broad survey using high-density tissue microarray technology,” Human Pathology, vol. 32, no. 7, pp. 690–697, 2001.
- H. He, X. Yang, A. J. Davidson et al., “Progressive epithelial to mesenchymal transitions in prostate cancer cells during xenograft tumor formation and metastasis,” The Prostate, vol. 70, no. 5, pp. 518–528, 2010.
- C. L. Chaffer, J. P. Brennan, J. L. Slavin, T. Blick, E. W. Thompson, and E. D. Williams, “Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2,” Cancer Research, vol. 66, no. 23, pp. 11271–11278, 2006.
- K. K. Tsai, J. Stuart, Y. Y. Chuang, J. B. Little, and Z. M. Yuan, “Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant,” Radiation Research, vol. 172, no. 3, pp. 306–313, 2009.
- L. E. Lamb, B. S. Knudsen, and C. K. Miranti, “E-cadherin-mediated survival of androgen-receptor-expressing secretory prostate epithelial cells derived from a stratified in vitro differentiation model,” Journal of Cell Science, vol. 123, no. 2, pp. 266–276, 2010.
- M. Matsuo, H. Sakurai, Y. Ueno, O. Ohtani, and I. Saiki, “Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin αv-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib,” Cancer Science, vol. 97, no. 2, pp. 155–162, 2006.