Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer

Table 2

Tissue expression modulations of the insulin/IGF system in ovarian cancer.

Insulin/IGF components	No. of patients	Modulation	Reference
Free IGF-I mRNA and protein	215 EOC	↑	[43]
IGF-I, IGF-IR mRNA, and several genes downstream of the receptor	64 EOC	↑	[44]
IGF-II mRNA	109 EOC	↑	[45]
IGF-II mRNA	215 EOC	↑	[46]
IGFBP3 protein	128 clear cell carcinoma	↑	[47]
IGFBP-2 mRNA	113 EOC	↑	[48]
IGFBP-3 protein	147 EOC	↓	[50]
IGFBP-3 protein	35 endometrioid carcinoma	↓	[51]

EOC: epithelial ovarian cancer.