Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas

Table 1

Proteins that are differentially expressed in N130-induced and-noninduced SKOV3 cells.

(a) Proteins downregulated by N130 induction

IPI	Protein name	ON-spectra	ON-peptides	OFF-spectra	OFF-peptides	Total spectra	Off/on
IPI00013881	Heterogeneous nuclear ribonucleoprotein H	4	5	20	7	24	4.62
IPI00012388	Transcription intermediary factor 1-beta	8	7	23	9	31	3.07
IPI00220985	Keratin, type I cytoskeletal 18	8	4	18	5	26	2.35
IPI00298547	RNA-binding protein regulatory subunit	10	7	23	7	33	2.30
IPI00299571	Protein disulfide isomerase A6	11	3	21	8	32	1.91
IPI00216976	aldolase C, fructose-bisphosphate	10	3	19	4	29	1.90
IPI00012074	Heterogeneous nuclear ribonucleoprotein R	9	5	17	7	26	1.89
IPI00013917	40S ribosomal protein S12	10	3	19	3	29	1.85
IPI00297779	T-complex protein 1, beta subunit	10	5	18	8	28	1.80
IPI00027434	Transforming protein RhoC	8	5	14	5	22	1.75
IPI00141318	P63 protein	8	6	13	5	21	1.73
IPI00219217	lactate dehydrogenase B	11	6	18	8	28	1.67
IPI00219096	high-mobility group box 1	15	4	25	5	40	1.67
IPI00009236	Caveolin-1	9	2	15	2	24	1.67
IPI00328343	Probable ATP-dependent RNA helicase p47	11	6	18	6	29	1.64
IPI00302927	T-complex protein 1, delta subunit	8	3	13	6	21	1.63
IPI00328188	fatty acid synthase	21	7	33	11	54	1.57
IPI00015027	AHNAK-related protein	11	7	17	11	27	1.55
IPI00017617	Probable RNA-dependent helicase p68	11	8	17	7	28	1.50

(b) Proteins upregulated by N130 induction

IPI	Protein name	ON-spectra	ON-peptides	OFF-spectra	OFF-peptides	Total spectra	On/off
IPI00017454	Hypothetical protein FLJ13940	23	4	0	0	23	?
IPI00045207	NAC1 protein	153	9	2	1	155	76.50
IPI00395440	Unknown	26	5	5	4	31	5.13
IPI00107117	Peptidylprolyl isomerase B	14	5	6	3	20	2.33
IPI00290566	T-complex protein 1, alpha subunit	14	6	6	3	20	2.33
IPI00176692	similar to Heterogeneous nuclear ribonucleoprotein A1	27	5	12	6	39	2.25
IPI00221088	ribosomal protein S9	17	6	8	6	25	2.13
IPI00215918	ADP-ribosylation factor 4	17	7	9	7	26	1.89
IPI00015786	Spectrin alpha chain, brain	53	27	30	18	83	1.77
IPI00152412	Hypothetical protein	14	4	8	5	22	1.75
IPI00020984	Calnexin	29	10	17	7	46	1.71
IPI00010896	Chloride intracellular channel protein 1	17	5	10	4	27	1.70
IPI00027626	T-complex protein 1, zeta subunit	18	9	11	9	29	1.64
IPI00216587	40S ribosomal protein S8	13	6	8	6	21	1.63
IPI00216318	tyrosine 3-monooxygenase	40	10	25	9	65	1.58
IPI00329351	60 kDa heat shock protein, mitochondrial	66	21	44	17	110	1.52
IPI00217468	H1 histone family, member 5	21	5	14	4	35	1.50
IPI00291006	Malate dehydrogenase, mitochondrial	15	6	10	4	25	1.50