Disrupting Ovarian Cancer Metastatic Colonization: Insights from Metastasis Suppressor Studies

Figure 1

Metastatic colonization is the final step in the development of metastases. After lodging at 2° sites, cells can either remain intravascular or extravasate. To form detectable metastases, disseminated cancer cells must activate signaling cascades, enabling them to survive, enter the cell cycle, and divide. Progressive growth requires the fraction of proliferating cells to exceed the fraction of cells that are nondividing or apoptotic,(Adapted from [4]).