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Table 4: Other Anti-EGFR antibodies explored in EOC.

Antibody Target Clinical data available Cetuximab ErbB1 Three phase II trials (one as a component of the first-line treatment and two performed in recurrence), alone or in combination with conventional cytotoxic therapy, have evidenced null or only modest impact of cetuximab in the management of EOC [44–46] Matuzumab ErbB1 One phase II study conducted in platinum-resistant, EGFR (+) population, concluded that matuzumab was well-tolerated, but lacked significant clinical activity [47] Pertuzumab Her2/neu One phase II trial involving advanced, refractory EOC patients has been conducted using this agent. Like matuzumab, pertuzumab was associated with a poor response rate (approximately 4%) [48]