Thyroid Cancer: Current Molecular Perspectives

Table 3

RET and MTC: Genotype-phenotype correlation.

RET receptor protein	RET mutation	CMT progression	Level of the risk of progression
Exon 10	Cys 609	Partially slow 5–7 years	High
	Cys 611
	Cys 618
	Cys 620
Exon 11	Cys 630	Intermediated ∼1 year
	Cys 634
Transmembrane domain	RETS649L	Slow 6–22 years	Intermediated
Exon 13	Glu 768 Asp
	Leu 790 Phe
	Tyr 791 Phe
Exon 14	Val 804 Met/Le
Exon 15	Ser 891 Ala
Exon 16	Met 918 Thr	Fast <1 year	Very high