Molecular Therapeutic Targets for Glioma Angiogenesis

<table>Hypoxia inducible factor 1<svg height="7.1750002" id="M9" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛼</tspan>
</text>
</g>
</g>
</svg> expression and hypoxic area with (b, d) and without (a, c) metronomic CPT11 treatment. HIF-1<svg height="7.1750002" id="M10" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛼</tspan>
</text>
</g>
</g>
</svg> expression and hypoxic area around the necrosis of glioma tissue decreased with treatment.</table>

Journal of Oncology

Molecular Therapeutic Targets for Glioma Angiogenesis

Figure 15