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Journal of Oncology
Volume 2010 (2010), Article ID 361836, 7 pages
http://dx.doi.org/10.1155/2010/361836
Review Article

Angiogenesis Inhibition in Prostate Cancer: Current Uses and Future Promises

1Division of Hematology and Oncology, Department of Medicine, The George Washington University Medical Center, 2150 Pennsylvania Avenue Northwest, Washington, DC 20037, USA
2Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
3Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

Received 31 October 2009; Accepted 30 December 2009

Academic Editor: Arkadiusz Dudek

Copyright © 2010 Jeanny B. Aragon-Ching et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Angiogenesis has been well recognized as a fundamental part of a multistep process in the evolution of cancer progression, invasion, and metastasis. Strategies for inhibiting angiogenesis have been one of the most robust fields of cancer investigation, focusing on the vascular endothelial growth factor (VEGF) family and its receptors. There are numerous regulatory drug approvals to date for the use of these agents in treating a variety of solid tumors. While therapeutic efficacy has been established, challenges remain with regards to overcoming resistance and assessing response to antiangiogenic therapies. Prostate cancer is the most common noncutaneous malignancy among American men and angiogenesis plays a role in disease progression. The use of antiangiogenesis agents in prostate cancer has been promising and is hereby explored.