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Journal of Oncology
Volume 2010 (2010), Article ID 396286, 13 pages
http://dx.doi.org/10.1155/2010/396286
Research Article

Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound

1Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
2Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
3Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
4Department of Cancer Prevention & Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Received 25 December 2009; Accepted 22 January 2010

Academic Editor: Arkadiusz Dudek

Copyright © 2010 Youcef M. Rustum et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Savage, J. Stebbing, M. Bower, and T. Crook, “Why does cytotoxic chemotherapy cure only some cancers?” Nature Clinical Practice Oncology, vol. 6, no. 1, pp. 43–52, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. O. Tredan, C. M. Galmarini, K. Patel, and I. F. Tannock, “Drug resistance and the solid tumor microenvironment,” Journal of the National Cancer Institute, vol. 99, no. 19, pp. 1441–1454, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Carmeliet and R. K. Jain, “Angiogenesis in cancer and other diseases,” Nature, vol. 407, no. 6801, pp. 249–257, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. R. K. Jain, “Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy,” Nature Medicine, vol. 7, no. 9, pp. 987–989, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Bhattacharya, M. Seshadri, S. D. Oven, K. Tóth, M. M. Vaughan, and Y. M. Rustum, “Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs,” Clinical Cancer Research, vol. 14, no. 12, pp. 3926–3932, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Bhattacharya, K. Tóth, R. Mazurchuk, et al., “Lack of microvessels in well-differentiated regions of human head and neck squamous cell carcinoma A253 associated with functional magnetic resonance imaging detectable hypoxia, limited drug delivery, and resistance to irinotecan therapy,” Clinical Cancer Research, vol. 10, no. 23, pp. 8005–8017, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Bhattacharya, K. Tóth, A. Sen, et al., “Inhibition of colon cancer growth by methylselenocysteine-induced angiogenic chemomodulation is influenced by histologic characteristics of the tumor,” Clinical Colorectal Cancer, vol. 8, no. 3, pp. 155–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Cao, F. A. Durrani, and Y. M. Rustum, “Selective modulation of the therapeutic efficacy of anticancer drugs by selenium containing compounds against human tumor xenografts,” Clinical Cancer Research, vol. 10, no. 7, pp. 2561–2569, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Bhattacharya, K. Tóth, F. A. Durrani, et al., “Hypoxia-specific drug tirapazamine does not abrogate hypoxic tumor cells in combination therapy with irinotecan and methylselenocysteine in well-differentiated human head and neck squamous cell carcinoma A253 xenografts,” Neoplasia, vol. 10, no. 8, pp. 857–865, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. M. M. Vaughan, K. Tóth, S. Chintala, and Y. M. Rustum, “Double immunohistochemical staining method for HIF-1a and its regulators PHD2 and PHD3 in formalin fixed paraffin embedded tissues,” Applied Immunohistochemistry and Molecular Morphology, 2010. View at Publisher · View at Google Scholar
  11. F. Demsar, T. P. L. Roberts, H. C. Schwickert, et al., “A MRI spatial mapping technique for microvascular permeability and tissue blood volume based on macromolecular contrast agent distribution,” Magnetic Resonance in Medicine, vol. 37, no. 2, pp. 236–242, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Seshadri, R. Mazurchuk, J. A. Spernyak, A. Bhattacharya, Y. M. Rustum, and D. A. Bellnier, “Activity of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid against human head and neck carcinoma xenografts,” Neoplasia, vol. 8, no. 7, pp. 534–542, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. U. Ozerdem and A. R. Hargens, “A simple method for measuring interstitial fluid pressure in cancer tissues,” Microvascular Research, vol. 70, no. 1-2, pp. 116–120, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-H. Heldin, K. Rubin, K. Pietras, and A. Ostman, “High interstitial fluid pressure—an obstacle in cancer therapy,” Nature Reviews Cancer, vol. 4, no. 10, pp. 806–813, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. B. D. Curti, W. J. Urba, W. G. Alvord, et al., “Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment,” Cancer Research, vol. 53, no. 10, pp. 2204–2207, 1993. View at Scopus
  16. F. G. Herrera, P. Chan, C. Doll, et al., “A prospective phase I-II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment,” International Journal of Radiation Oncology Biology Physics, vol. 67, no. 1, pp. 97–103, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Brambilla, D. Moro, S. Gazzeri, et al., “Cytotoxic chemotherapy induces cell differentiation in small-cell lung carcinoma,” Journal of Clinical Oncology, vol. 9, no. 1, pp. 50–61, 1991. View at Scopus
  18. R. G. Azrak, S. Cao, H. K. Slocum, et al., “Therapeutic synergy between irinotecan and 5-fluorouracil against human tumor xenografts,” Clinical Cancer Research, vol. 10, no. 3, pp. 1121–1129, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. C. A. Kanashiro, A. V. Schally, M. Zarandi, B. D. Hammann, and J. L. Varga, “Suppression of growth of H-69 small cell lung carcinoma by antagonists of growth hormone releasing hormone and bombesin is associated with an inhibition of protein kinase C signaling,” International Journal of Cancer, vol. 112, no. 4, pp. 570–576, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Mayer, M. Höckel, and P. Vaupel, “Carbonic anhydrase IX expression end tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix,” Clinical Cancer Research, vol. 11, no. 20, pp. 7220–7225, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Hedley, M. Pintilie, J. Woo, et al., “Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas,” Clinical Cancer Research, vol. 9, no. 15, pp. 5666–5674, 2003. View at Scopus
  22. S. Kaluz, M. Kaluzová, S.-Y. Liao, M. Lerman, and E. J. Stanbridge, “Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show?” Biochimica et Biophysica Acta, vol. 1795, no. 2, pp. 162–172, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. H. M. W. Verheul and H. M. Pinedo, “Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition,” Nature Reviews Cancer, vol. 7, no. 6, pp. 475–485, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. L. M. Ellis and D. A. Reardon, “Cancer: the nuances of therapy,” Nature, vol. 458, no. 7236, pp. 290–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Paez-Ribes, E. Allen, J. Hudock, et al., “Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis,” Cancer Cell, vol. 15, no. 3, pp. 220–231, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. M.-B. Yin, Z.-R. Li, K. Tóth, et al., “Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2, inducible nitric oxide synthase, and hypoxia-inducible factor 1α expression, resulting in reduced angiogenesis,” Oncogene, vol. 25, no. 17, pp. 2509–2519, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. P. D. Whanger, “Selenium and its relationship to cancer: an update,” The British Journal of Nutrition, vol. 91, no. 1, pp. 11–28, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Chintala, K. Tth, S. Cao, et al., “Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α,” Cancer Chemotherapy and Pharmacology, 2010. View at Publisher · View at Google Scholar
  29. M. I. Jackson and G. F. Combs Jr., “Selenium and anticarcinogenesis: underlying mechanisms,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 11, no. 6, pp. 718–726, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. M. G. Fakih, L. Pendyala, W. Brady, et al., “A phase I and pharmacokinetic study of selenomethionine in combination with a fixed dose of irinotecan in solid tumors,” Cancer Chemotherapy and Pharmacology, vol. 62, no. 3, pp. 499–508, 2008. View at Publisher · View at Google Scholar · View at Scopus