Review Article
Burkitt Lymphoma: Pathogenesis and Immune Evasion
Table 1
Factors may contribute to the defects in immune recognition of BL cells.
| Factor | Cells Affected | Function(s)/defect(s) in Immune Evasion |
| EBNA1 | 90% eBL | Negative regulation of own mRNA translation [64] | 5–10% sBL | Internal gly-ala repeat blocks proteasomal degradation and consequent | 40% HIV associated BL | HLA class I presentation [63] |
| C-myc | All BL | Downregulation of HLA class I [30] | Antagonism of NF-B pathway | Negative regulation of STAT1 signaling | Impairment of interferon response [59] | Downregulation of accessory molecules important in immune response: LFA-1, LFA-3, ICAM-1, and TAP [86–90] |
| HLA class I | All BL | Down-regulated in BL [71–74] | Downregulation of CD80/86 in BL decreases HLA class I signaling |
| HLA class II | All BL | Downregulation of CD80/86 in BL decreases HLA class II signaling | Upregulation of HLA-DO causes decrease in formation of class | II/peptide complexes [91, 92] BLAIM may impair functional Ag | presentation by HLA class II (unpublished data). |
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