Claudin Family of Proteins and Cancer: An Overview

Table 1

Expression of Claudins in Cancer.

Type of Malignancy	Claudin gene		Expression
Breast Carcinoma	CLDN1		Down
	CLDN3		Up
	CLDN4		Up
	CLDN7		Down
Biliary tract Carcinoma	CLDN4		Up
Colorectal Carcinoma	CLDN1		Up
	CLDN8		Down
	CLDN12		Up
Endometrial endometrioid Carcinoma	CLDN1		Down
	CLDN2		Up
Endometrial seropapillary Carcinoma	CLDN1		Up
	CLDN2		Down
Gastric adenocarcinoma	CLDN1		Up
	CLDN3		Up
	CLDN4		Up
	CLDN5		Up
Hepatocellular carcinoma	CLDN4		Down
	CLDN7		Up
Hepatoblastoma (Fetal)	CLDN1		Up
	CLDN2		Up
	CLDN3		Down
	CLDN4		Down
	CLDN7		Down
Head & Neck (SCC)	CLDN7		Down
Lung cancer (Adenocarcinoma)	CLDN1		Down
	CLDN5		Up
Lung cancer (SCC)	CLDN1		Up
	CLDN5		Down
Meningioma	CLDN1		Up
Mesothelioma	CLDN4		Down
	CLDN5		Down
Metastatic Melanoma	CLDN1		Down
Oncocytoma	CLDN7		Down
	CLDN8		Up
Ovarian epithelial Carcinoma	CLDN1		Up
	CLDN3		Up
	CLDN4		Up
	CLDN5		Up
	CLDN7		Up
Ovarian sex cord stromal Tumors	CLDN1		Down
	CLDN3		Down
	CLDN4		Down
	CLDN5		Down
Pancreatic Carcinoma	CLDN1		Up
	CLDN4		Up
Pleura (metastatic adenocarcinoma)	CLDN3		UP
	CLDN4		UP
Prostate Carcinoma	CLDN1		Up
	CLDN2		Down
	CLDN3		Up
	CLDN4		Up
	CLDN5		Down
	CLDN7		Up
Renal cell Carcinoma	CLDN1		Up
	CLDN3		Up
	CLDN4		Up
Renal cell Carcinoma (Chromobhobe)	CLDN7		Up
Tongue (SCC)	CLDN1		Up
	CLDN4		Up
	CLDN7		Up
Thyroid Carcinomas	CLDN1		Up
	CLDN4		Up
	CLDN7		Up
Undifferentiated Thyroid Carcinoma	CLDN1		Down