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Journal of Oncology
Volume 2010 (2010), Article ID 652320, 12 pages
http://dx.doi.org/10.1155/2010/652320
Review Article

Molecular and Clinical Aspects of Targeting the VEGF Pathway in Tumors

1Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland
2Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Received 25 November 2009; Accepted 21 April 2010

Academic Editor: Arkadiusz Dudek

Copyright © 2010 Grzegorz Korpanty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tumor angiogenesis is a complex process resulting from many signals from the tumor microenvironment. From preclinical animal models to clinical trials and practice, targeting tumors with antiangiogenic therapy remains an exciting area of study. Although many scientific advances have been achieved, leading to the development and clinical use of antiangiogenic drugs such as bevacizumab, sorafenib, and sunitinib, these therapies fall short of their anticipated benefits and leave many questions unanswered. Continued research into the complex signaling cascades that promote tumor angiogenesis may yield new targets or improve upon current therapies. In addition, the development of reliable tools to track tumor responses to antiangiogenic therapy will enable a better understanding of current therapeutic efficacy and may elucidate mechanisms to predict patient response to therapy.