Review of drugs in the epidermal growth factor receptor family that have been evaluated in ovarian cancer. RR: response rate, SD: stable disease, HTN: hypertension.
Agent(s)
Authors
RR
SD
Toxicities
Gefitinib
Schilder et al.
1/27
Dermatologic, diarrhea
Gefitinib + tamoxifen
Wagner et al.
0/56
16/56
Diarrhea, skin rash
Erlotinib
Gordon et al.
2/34 partial
15/34
Rash, diarrhea
Erlotinib + bevacizumab
Nimeiri et al.
1/13 complete
7/13
Anemia, nausea, vomiting, HTN, diarrhea, 2 fatal GI perforations
