Research Article
Effects of HIF-1 and HIF2 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts
Figure 1
Features of CCRCC 786-0 tumors. (a–d) (x100 hpf) HIF-1 nuclear staining only ). (e–h) Differential HIF-2 nuclear staining ). (i) Clear-cell/sarcomatoid morphology (x40 hpf). (j) CD10+ staining typical of clear-cell RCC lineage (x100 hpf). (k) PTEN staining; positive staining only identified in murine fibroblasts (x100 hpf). (l) Akt staining, (m) Phospho-Ser473 Akt staining (highest in HIF-2+ tumors). values were calculated using an ANOVA test.