Effects of HIF-1𝛼 and HIF2𝛼 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

Table 1

Metabolite levels measured by ${}_{}{}^{\text{1}}\text{H}$ MRS in 786-0 tumor extracts.

Metabolite	EV	HIF-1+	HIF-2+
Leucine	$0.13\pm 0.01$	$0.17\pm 0.02$	$0.17\pm {0.01}^{\text{a}}$
Iso Leucine	$0.06\pm 0.01$	$0.08\pm 0.005$	$0.08\pm {0.005}^{\text{a}}$
Lactate	$5.13\pm 0.85$	$5.43\pm 0.51$	$2.54\pm {0.58}^{\text{a},\text{b}}$
Alanine	$0.84\pm 0.06$	$0.88\pm 0.05$	$0.63\pm {0.04}^{\text{a},\text{b}}$
Choline	$0.17\pm 0.02$	$0.22\pm 0.04$	$0.29\pm {0.05}^{\text{a}}$
PC	$0.73\pm 0.09$	$0.66\pm 0.14$	$1.14\pm {0.05}^{\text{a},\text{b}}\mathrm{\hspace{0.17em}\hspace{0.17em}}$
Taurine	$13.96\pm 1.55$	$13.02\pm 0.92$	$16.70\pm {0.66}^{\text{b}}$
Cr	$1.26\pm 0.14$	$1.46\pm 0.15$	$2.00\pm {0.17}^{\text{a},\text{b}}$
Glucose	$0.63\pm 0.10$	$0.73\pm 0.12$	$1.19\pm {0.29}^{\text{a}}$
ATP+ADP	$0.91\pm 0.20$	$0.95\pm 0.13$	$1.14\pm 0.15$

Metabolites expressed as $\mu$mol/g wet weight tissue (n = 3–5). ${}_{}{}^{\text{a}}\text{d}$enotes statistically significant different from EV and ${}_{}{}^{\text{b}}\text{d}$enotes statistically significant difference ($P<.05$) from HIF-1+. A two-tailed t test was used for significance levels.