Effects of HIF-1𝛼 and HIF2𝛼 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

Table 2

Overview of molecular characteristics of HIF-1α and HIF-2α expression on CCRCC 786-0 xenografts compared to EV xenografts.

Parameter	Marker	HIF-1+	HIF-2+
Growth	volume	$\downdownarrows$	$\upuparrows$
	Ki67	$\downarrow$	$\downarrow$
	Cyclin D1	—	$\upuparrows$
Apoptosis	Caspase-3	$<$0.5%	<0.5%
Autophagy	BNIP3	$\uparrow$	$\downdownarrows$
Glycolysis	GLUT-1	—	$\downdownarrows$
	HK II	—	$\downdownarrows$
	LDH5	—	$\downdownarrows$
	Lactate	—	$\downdownarrows$
	Glucose	—	$\upuparrows$
Mitochondrial Respiration	PDH/PDK	$\downarrow$	$\upuparrows$
	TOM-20	—	$\upuparrows$
ROS	8-OH-guanosine	$\downarrow$	$\uparrow$
DNA	$\gamma$H2A.X	$\uparrow$	$\downdownarrows$
damage/repair	OGG1	—	$\upuparrows$
Angiogenesis	VEGF	—	$\upuparrows$
	CD31	—	$\upuparrows$