Short-Term Exposure to Tobacco Toxins Alters Expression of Multiple Proliferation Gene Markers in Primary Human Bronchial Epithelial Cell Cultures

Table 4

Percent staining for TP53-positive cells.

TP53	Percent (%)
	Positive small cells	Negative small cells	Positive large cells	Negative large cells
Nickel sulphate 24 hr	98.3	1.6	19	1
Nickel sulphate 48 hr	95.6	4.3	20	0
Benzo(b)fluoranthene 24 hr	68	32	19.3	0.6
Benzo(b)fluoranthene 48 hr	82.6	17.3	17.3	2.6
N-nitrosodiethylamine 24 hr	82.3	27.6	17.3	2.6
N-nitrosodiethylamine 48 hr	64.6	35.3	17.6	2.3
NNK 24 hr	92	8	17.6	2.3
NNK 48 hr	98.6	1.3	19.6	0.3

All values expressed as percentages.