Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

Figure 1

MAL3-101 induces a graded cytotoxic effect in multiple myeloma (MM) cell lines. (a) MM cell lines (1×10⁵) were exposed to 10 μM MAL3-101 for the indicated culture periods, and the fold change in percent viable cells in treated versus control cells was determined by an MTS assay. (b) NCI-H929 cells were exposed to the indicated concentrations of MAL3-101 or MAL3-51 for 40 h, and the percent viability, as compared to control, DMSO-treated cells, was assessed by an MTS assay. Data are presented as means and SDs from three independent experiments; *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001.

(a)

(b)