Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis

Figure 3

Protein binding sites within the intracellular region of E-cadherin. The cytoplasmic domain of E-cadherin contains binding sites for a variety of signalling molecules, thus facilitating its role in signal transduction. Abbreviations: S: signal peptide, PRO: propeptide, EC: extracellular domain, TM: transmembrane domain, N: N-terminus, C: C-terminus, β-cat: β-catenin, HAV: histidine-alanine-valine, BD: binding domain, PS1: presenilin 1, PIPKIγ: type Iγ phosphatidylinositol phosphate kinase, PTPμ: protein tyrosine phosphate μ, AA: amino acid, CK: casein kinase, PKD: protein kinase D. Adapted from Van Roy and Berx [3].