Review Article
Lipid Mediators and Human Leukemic Blasts
Figure 1
Simplified representation of the pathways involved in eicosanoid and platelet-activating factor formation and signal transduction. Enzymatic activities and receptors are in rectangles and ovals, respectively. PLA2, phospholipase A2; COX, cyclooxygenase; LOX, lipoxygenase; PGH2, prostaglandin H2; PGE2, prostaglandin E2; PGI2, prostacyclin; TXA2, thromboxane A2; HPETE, hydroperoxyeicosatetraenoic acid; LTB4, leukotriene B4; HETE, hydroxyeicosatetraenoic acid; PAF, platelet-activating factor; PAFR, PAF receptor; EP1-4, subtype 1–4 of the PGE2 receptor; IP, PGI2 receptor; TXA2R, TXA2 receptor; BLT1-2, subtype 1 and 2 of the LTB4 receptor.
