Simplified representation of the relationships between lipid mediators and leukemic blasts. Leukemic cells express several cPLA2 and sPLA2. COX activities can metabolise AA into PGE2 and TXA2. LOX activities can metabolise AA into LTB4 and 12-HETE. Leukemic cells can release PAF. Functional TXA2, IP, EP2, PAF, and PLA2 receptors are found on leukemic cells. BLT1 and BLT2 transcripts are detected suggesting (?) LTB4 receptors. The immunoregulatory effects of lipid mediators are currently speculative except for the role of PGE2 on AML blast growth. Related references are in square brackets.
