Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells

Table 1

Case description, tumorigenic characteristics and treatment effects of ALDH1⁺ and ALDH1^- HNSCC.

				Number of cells injected
Case	Age/Sex	ALDH^+ (%)	Spheres	Parental	ALDH1^+	ALDH1^+ (Sh-Bmi 1)	ALDH1^-	ALDH1^- (Bmi 1Over)
			Formation
1	71/ M	44.2	Yes	1,000 (0/3)	1,000 (1/3)	1,000 (0/3)	1,000 (0/3)	1,000 (1/3)
				3,000 (0/3)	3,000 (3/3)	3,000 (0/3)	3,000 (0/3)	3,000 (1/3)
				10,000 (1/3)	10,000 (3/3)	10,000 (2/3)	10,000 (1/3)	10,000 (2/3)
2	73/ F	24.7	Yes	1,000 (0/3)	1,000 (1/3)	1,000 (1/3)	1,000 (0/3)	1,000 (0/3)
				3,000 (0/3)	3,000 (2/3)	3,000 (2/3)	3,000 (0/3)	3,000 (1/3)
				10,000 (2/3)	10,000 (2/3)	10,000 (2/3)	10,000 (0/3)	10,000 (2/3)
3	61 / F	8.6	Yes	1,000 (0/3)	1,000 (1/3)	1,000 (1/3)	1,000 (0/3)	1,000 (0/3)
				3,000 (0/3)	3,000 (3/3)	3,000 (1/3)	3,000 (0/3)	3,000 (2/3)
				10,000 (0/3)	10,000 (3/3)	10,000 (2/3)	10,000 (0/3)	10,000 (3/3)
4	71 / M	1.2	Yes	1,000 (0/3)	1,000 (0/3)	1,000 (0/3)	1,000 (0/3)	1,000 (0/3)
				3,000 (0/3)	3,000 (3/3)	3,000 (0/3)	3,000 (0/3)	3,000 (2/3)
				10,000 (0/3)	10,000 (3/3)	10,000 (2/3)	10,000 (0/3)	10,000 (3/3)
5	69 / M	19.2	Yes	1,000 (0/3)	1,000 (1/3)	1,000 (0/3)	1,000 (0/3)	1,000 (0/3)
				3,000 (0/3)	3,000 (3/3)	3,000 (1/3)	3,000 (0/3)	3,000 (2/3)
				10,000 (1/3)	10,000 (3/3)	10,000 (2/3)	10,000 (0/3)	10,000 (3/3)
6	72 / M	5.5	Yes	1,000 (0/3)	1,000 (1/3)	1,000 (0/3)	1,000 (0/3)	1,000 (0/3)
				3,000 (0/3)	3,000 (3/3)	3,000 (1/3)	3,000 (0/3)	3,000 (2/3)
				10,000 (0/3)	10,000 (3/3)	10,000 (1/3)	10,000 (0/3)	10,000 (2/3)

ALDH1⁺: ALDH1-positive HNSCC cells; ALDH1^-: ALDH1-negative HNSCC cells.
ALDH1⁺ or ALDH1⁺ cells were injected into neck of SCID mice.