Gene Expression Differences between Enriched Normal and Chronic Myelogenous Leukemia Quiescent Stem/Progenitor Cells and Correlations with Biological Abnormalities

Table 2

List of genes, discussed in the paper, with significantly differential gene expression in CML CD34+/G0 cells compared to normal bone marrow. The fold change is linear and positive values mean genes more expressed in CML and negative values vice versa. In the case that for one gene there is more than one set of probes significantly differentially expressed, we reported the highest value among them. For the complete list of genes, see Supplementary Material available online at doi:10.1155/2011/798592.

Gene symbol	Fold change (CML/BM)	Gene symbol	Fold change (CML/BM)
Apoptosis		HLA-E	−2.81
FAS	+2.9	HOXA3	−4.44
MX1	−3	HOXB6	−4.97
BIRC3	−3.1	SPINK2	−10.71
MALT1	−4.44	NRIP1	−2.41
NALP1	−2.29	PRKCH	−6.43
Cell proliferation		RAPGEF2	−2.6
MTSS1	+5.58	TLOC1	−1.77
DLG7	+3.71	HES-1	−8.45
ANLN	+3.56	Differentiation
CCNB2	+3.34	CD36	+19.7
CDC6	+3.28	XK	+8.7
CETN3	+3.16	Klf1	+6.97
MAP9	−3.51	ITGA2B (CD41)	+6.51
MAP9	−3.51	GATA1	+4.0
CDC14B	−5.18	NFE2	+3.3
DNA replication		TESC	+4.5
RRM2	+5.57	ANK1	+3.9
GINS1	+3.49	HBQ1	+3.2
TOPO2A	+3.34	HBD	+18.4
GINS2	+3.33	HBG1	+17.3
Growth factors/cytokines		HBB	+13.4
IL7	+3.26	NCF4	+3.9
Stem cell markers		BCL6	−4.88
PROM1	−19.75	GATA3	−4.99
HLF	−18.08	TFR2	+5.5
GBP2	−3.85	LEPR	+20.6
FLT3	−6.6	*SMAD7	−8.7
SPTBN1	−4.97	*NMYC	−4.1
RBPMS	−5.93	Transcription factors
GATA3	−4.99	HOXB3	−3.23
MPL (CD110)	−6.11	HOXA5	−3.76
TNFSF10 (TRAIL)	−3.07	WT1	+3.7
MSI2	−4.18	Cancer genes
ID1	−7.32	PVT1	+7.0
ARG2	−2.92	ANXA2	+5.75
BIRC3	−3.88	MARCKS	+8.21
CRHBP	−14.75