Targeting the Mechanisms of Resistance to Chemotherapy and Radiotherapy with the Cancer Stem Cell Hypothesis

Figure 3

Schematic diagram of the canonical Wnt/𝛽-catenin signaling. Wnt/𝛽-catenin pathway may promote genomic instability after irradiation, thus allowing tumor cells to both survive after irradiation and develop additional adaptive mutations. ICG-001, PKF115-854, and CGP049040 are anticancer drugs in development that target the Wnt signaling pathway.