Targeting the Mechanisms of Resistance to Chemotherapy and Radiotherapy with the Cancer Stem Cell Hypothesis

Table 1

Update on clinical trials for CSC molecular targets.

Target	Drug	Cancer	Phase	http://clinicaltrials.gov/	Sponsor
				Identifier
Wnt	Resveratrol	Colon	I, II	NCT00256334	University of California, Irvine
Notch	MK0752	Breast	I	NCT00106145	Merck
		Pancreatic	I, II	NCT01098344	Cancer Research UK
	RO4929097	Renal cell	II	NCT01141569	University Health Network, Toronto
	PF-03084014	Leukemia	I	NCT00878189	Pfizer
Hedgehog	GDC-0449	Solid tumors	I	NCT00968981	Genentech
		Colorectal	II	NCT00636610	Genentech
	PF-04449913	Hematologic	I	NCT00953758	Pfizer
	BMS-833923	Basal cell	I	NCT00670189	Bristol-Myers Squibb
	LDE225	Medulloblastoma	I	NCT00880308	Novartis