Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung

Figure 1

Hypermethylation of four genes in noncancerous lung tissues. Percent of subjects with hypermethylation of four genes (APC, CCND2, CDH1, and RARB), stratified by smoking status. Samples were considered to be positive for any hypermethylation at PMR >0%. To provide population statistics, one lung tissue sample per subject was randomly selected. The 15 other genes tested were hypermethylated in <2% of all subjects.