Review Article
Folate and Colorectal Cancer in Rodents: A Model of DNA Repair Deficiency
Table 3
Impact of dietary intervention on blood and colon folate status.
| Percent change in blood folate status by dietary intervention |
| 2 mg/kg to 0 mg/kg | ↓96% | Rat | 20 wk | (with either abx or wire bottom cages) | ↓96% | Rat | 11 wk | | ↓92% | Mouse | 8 wk | [21, 75, 76, 83, 85] | ↓50% | Rat | 8 wk | | ↓81% | Rat | 24 wk |
| 2 mg/kg to 0 mg/kg | ↓69% | Mouse | 12 wk | (without abx or wire bottom cages) | ↓63%* | Mouse | 5 wk | ↓78%* | Mouse | 11 wk | [68, 77, 84] | ↓35%** | Mouse | 16 wk |
| 2 mg/kg to 8 mg/kg | ↑58% | Rat | 20 wk | (with either abx or wire bottom cages) | ↑62% | Rat | 8 wk | [75, 76, 83] | ↑140% | Rat | 24 wk |
| 2 mg/kg to 8 mg/kg | | | | (without abx or wire bottom cages) | ↑44% | Mouse | 12 wk | [77] | | | |
| Percent change in colon folate status by dietary intervention |
| 2 mg/kg to 0 mg/kg | ↓72% | Rat | 20 wk | (with either abx or wire bottom cages) | ↓35% | Rat | 8 wk | [75, 83] | | | |
| 2 mg/kg to 0 mg/kg | ↓74%* | Mouse | 5 wk | (without abx or wire bottom cages) | ↓40%** | Mouse | 16 wk | [68, 84] | | | |
| 2 mg/kg to 8 mg/kg | ↑19% | Rat | 20 wk | (with either abx or wire bottom cages) | ↑66% | Rat | 8 wk | [75, 83] | | | |
| 2 mg/kg to 8 mg/kg | | | | (without abx or wire bottom cages) | | | |
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Abx: antibiotics; wk: week; *choline also depleted in this dietary intervention; **riboflavin, B6, and B12 also modified in this dietary intervention.
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