Integrin-Mediated Cell-Matrix Interaction in Physiological and Pathological Blood Vessel Formation

Figure 3

Options to manipulate integrin function. Essential cellular functions, such as adhesion, migration, proliferation, and survival, which all are regulated by integrins, can pharmacologically be manipulated with a panoply of matrikines, antibodies, peptides, and small molecule inhibitors, many of which are used as therapeutic tools in combination with conventional chemo- or radiotherapy to attack tumor cells and vasculature. Details are described in the text.