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Journal of Oncology
Volume 2012 (2012), Article ID 128608, 9 pages
http://dx.doi.org/10.1155/2012/128608
Review Article

Angiogenesis in Acute Myeloid Leukemia and Opportunities for Novel Therapies

Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610-0278, USA

Received 2 May 2011; Revised 3 July 2011; Accepted 5 July 2011

Academic Editor: Arkadiusz Dudek

Copyright © 2012 Angelica Trujillo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. J. Jabbour, E. Estey, and H. M. Kantarjian, “Adult acute myeloid leukemia,” Mayo Clinic Proceedings, vol. 81, no. 2, pp. 247–260, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Lowenberg, J. R. Downing, and A. Burnett, “Acute myeloid leukemia,” The New England Journal of Medicine, vol. 341, no. 14, pp. 1051–1062, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. F. R. Appelbaum, H. Gundacker, D. R. Head et al., “Age and acute myeloid leukemia,” Blood, vol. 107, no. 9, pp. 3481–3485, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. J. Hoggatt and L. M. Pelus, “Mobilization of hematopoetic stem cells from the bone marrow niche to the blood compartment,” Stem Cell Research and Therapy, vol. 2, no. 2, p. 13, 14.
  5. F. Ayala, R. Dewar, M. Kieran, and R. Kalluri, “Contribution of bone microenvironment to leukemogenesis and leukemia progression,” Leukemia, vol. 23, pp. 2233–2241, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. W. Fiedler, U. Graeven, S. Ergün et al., “Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia,” Blood, vol. 89, no. 6, pp. 1870–1875, 1997. View at Scopus
  7. J. W. Hussong, G. M. Rodgers, and P. J. Shami, “Evidence of increased angiogenesis in patients with acute myeloid leukemia,” Blood, vol. 95, no. 1, pp. 309–313, 2000. View at Scopus
  8. T. T. F. Shih, H. A. Hou, C. Y. Liu et al., “Bone marrow angiogenesis magnetic resonance imaging in patients with acute myeloid leukemia: peak enhancement ratio is an independent predictor for overall survival,” Blood, vol. 113, no. 14, pp. 3161–3167, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. T. Padro, R. M. Mesters, R. Bieker et al., “Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia,” Blood, vol. 95, no. 8, pp. 2637–2644, 2000. View at Scopus
  10. I. Kuzu, M. Beksac, M. Arat, H. Celebi, A. H. Elhan, and S. Erekul, “Bone marrow microvessel density (MVD) in adult acute myeloid leukemia (AML): therapy induced changes and effects on survival,” Leukemia and Lymphoma, vol. 45, no. 6, pp. 1185–1190, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. J. L. Liesveld, K. E. Rosell, C. Lu et al., “Acute myelogenous leukemia-microenvironment interactions: role of endothelial cells and proteasome inhibition,” Hematology, vol. 10, no. 6, pp. 483–494, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. K. Hatfield, A. M. Øyan, E. Ersvaer et al., “Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators,” British Journal of Haematology, vol. 144, no. 1, pp. 53–68, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. R. C. Kruizinga, H. J. de Jonge, K. R. Kampen, A. M. Walenkamp, and E. S. de Bont, “Vascular endothelial growth factor a isoform mRNA expression in pediatric acute myeloid leukemia,” Pediatric Blood and Cancer, vol. 56, no. 2, pp. 294–297, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. A. R. Perez, S. E. Sallan, U. Tedrow, S. Connors, E. Allred, and J. Folkman, “Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia,” American Journal of Pathology, vol. 150, no. 3, pp. 815–821, 1997. View at Scopus
  15. G. J. Madlambayan, A. M. Meacham, K. Hosaka et al., “Leukemia regression by vascular disruption and antiangiogenic therapy,” Blood, vol. 116, no. 9, pp. 1539–1547, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. W. Hou, W. C. Chou, L. I. Lin et al., “Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia,” Leukemia Research, vol. 32, no. 6, pp. 904–912, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. S. Loges, G. Heil, M. Bruweleit et al., “Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival,” Journal of Clinical Oncology, vol. 23, no. 6, pp. 1109–1117, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. S. Mourah, R. Porcher, G. Lescaille et al., “Quantification of VEGF isoforms and VEGFR transcripts by qRT-PCR and their significance in acute myeloid leukemia,” International Journal of Biological Markers, vol. 24, no. 1, pp. 22–31, 2009.
  19. T. Padro, R. Bieker, S. Ruiz et al., “Overexpression of vascular endothelial growth factor (VEGF) and its cellular receptor KDR (VEGFR-2) in the bone marrow of patients with acute myeloid leukemia,” Leukemia, vol. 16, no. 7, pp. 1302–1310, 2002. View at Publisher · View at Google Scholar · View at PubMed
  20. S. Dias, K. Hattori, Z. Zhu et al., “Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration,” Journal of Clinical Investigation, vol. 106, no. 4, pp. 511–521, 2000.
  21. M. Wakabayashi, H. Miwa, M. Shikami et al., “Autocrine pathway of angiopoietins-Tie2 system in AML cells,” The Hematology Journal, vol. 5, no. 4, pp. 353–360, 2004. View at Publisher · View at Google Scholar · View at PubMed
  22. H. Reikvam, K. J. Hatfield, P. Lassalle, A. Olsnes Kittang, E. Ersvær, and Ø. Bruserud, “Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release,” Expert Opinion on Investigational Drugs, vol. 19, no. 2, pp. 169–183, 2010. View at Publisher · View at Google Scholar · View at PubMed
  23. C. Morrissey, A. Dowell, T. D. Koreckij et al., “Inhibition of angiopoietin-2 in Lucap 23.1 prostate cancer tumors decreases tumor growth and viability,” The Prostate, vol. 70, no. 16, pp. 1799–1808, 2010.
  24. A. M. Skinner, D. C. Goldman, A. McBeth, M. J. Shurtleff, H. W. Fleming, and P. Kurre, “Hematopoeitic cells undergo homotypic cell fusion: a novel platform to study genomic instability in leukemogenesis,” in The American Society of Hematology, Orange County Convention Center, Orlando, Fla, USA, 2010.
  25. C. Lancrin, P. Sroczynska, A. G. Serrano et al., “Blood cell generation from the hemangioblast,” Journal of Molecular Medicine, vol. 88, no. 2, pp. 167–172, 2010. View at Publisher · View at Google Scholar · View at PubMed
  26. A. Bailey, H. Willenbring, S. Jiang et al., “Myeloid lineage progenitors give rise to vascular endothelium,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 35, pp. 13156–13161, 2006. View at Publisher · View at Google Scholar · View at PubMed
  27. C. R. Cogle, D. A. Wainman, M. L. Jorgensen, S. M. Guthrie, R. N. Mames, and E. W. Scott, “Adult human hematopoietic cells provide functional hemangioblast activity,” Blood, vol. 103, no. 1, pp. 133–135, 2004. View at Publisher · View at Google Scholar · View at PubMed
  28. C. R. Cogle and E. W. Scott, “The hemangioblast: cradle to clinic,” Experimental Hematology, vol. 32, no. 10, pp. 885–890, 2004. View at Publisher · View at Google Scholar · View at PubMed
  29. M. B. Grant, W. S. May, S. Caballero et al., “Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization,” Nature Medicine, vol. 8, no. 6, pp. 607–612, 2002. View at Publisher · View at Google Scholar · View at PubMed
  30. A. S. Bailey, S. Jiang, M. Afentoulis et al., “Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells,” Blood, vol. 103, no. 1, pp. 13–19, 2004. View at Publisher · View at Google Scholar · View at PubMed
  31. B. Fang, C. Zheng, L. Liao et al., “Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics,” Blood, vol. 105, no. 7, pp. 2733–2740, 2005. View at Publisher · View at Google Scholar · View at PubMed
  32. M. C. Yoder, L. E. Mead, D. Prater et al., “Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals,” Blood, vol. 109, no. 5, pp. 1801–1809, 2007. View at Publisher · View at Google Scholar · View at PubMed
  33. J. Otten, A. Schultze, P. Schafhausen et al., “Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative,” British Journal of Haematology, vol. 142, no. 1, pp. 115–118, 2008. View at Publisher · View at Google Scholar · View at PubMed
  34. J. Karp, I. Gojo, R. Pili et al., “Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: therapy with sequential 1-β-D-arabinofuranosylcytosine, mitoxantrone, and bevacizumab,” Clinical Cancer Research, vol. 10, no. 11, pp. 3577–3585, 2004. View at Publisher · View at Google Scholar · View at PubMed
  35. R. M. Mesters, L. Zahiragic, C. Schliemann et al., “Bevacizumab reduces VEGF expression in patients with relapsed and refractory acute myeloid leukemia without clinical antileukemic activity,” Leukemia, vol. 21, no. 6, pp. 1310–1312, 2007. View at Publisher · View at Google Scholar · View at PubMed
  36. A. C. Lockhart, M. L. Rothenberg, J. Dupont et al., “Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors,” Journal of Clinical Oncology, vol. 28, no. 2, pp. 207–214, 2010. View at Publisher · View at Google Scholar · View at PubMed
  37. W. Fiedler, H. Serve, H. Dohner et al., “A phase I study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease,” Blood, vol. 105, no. 3, pp. 986–993, 2005. View at Publisher · View at Google Scholar · View at PubMed
  38. W. Fiedler, R. Mesters, H. Tinnefeld et al., “A phase 2 clinical study of SU5416,” Blood, vol. 102, no. 8, pp. 2763–2767, 2003. View at Publisher · View at Google Scholar · View at PubMed
  39. F. Ravandi, J. E. Cortes, D. Jones et al., “Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia,” Journal of Clinical Oncology, vol. 28, no. 11, pp. 1856–1862, 2010. View at Publisher · View at Google Scholar · View at PubMed
  40. S. K. Metzelder, E. Wollmer, A. Neubauer, and A. Burchert, “Sorafenib in relapsed and refractory FLT3-ITD positive acute myeloid leukemia: a novel treatment option,” Deutsche Medizinische Wochenschrift, vol. 135, no. 38, pp. 1852–1856, 2010. View at Publisher · View at Google Scholar · View at PubMed
  41. E. Chan, D. Mulkerin, M. Rothenberg et al., “A phase I trial of CEP701+ gemcitabine in patients with advanced adenocarcinoma of the pancreas,” Investigational New Drugs, vol. 26, no. 3, pp. 241–247, 2008. View at Publisher · View at Google Scholar · View at PubMed
  42. F. J. Giles, W. T. Bellamy, Z. Estrov et al., “The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS),” Leukemia Research, vol. 30, no. 7, pp. 801–811, 2006. View at Publisher · View at Google Scholar · View at PubMed
  43. G. J. Roboz, F. J. Giles, A. F. List et al., “Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome,” Leukemia, vol. 20, no. 6, pp. 952–957, 2006. View at Publisher · View at Google Scholar · View at PubMed
  44. I. Petit, M. A. Karajannis, V. Loit et al., “The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death,” Blood, vol. 111, no. 4, pp. 1951–1961, 2008. View at Publisher · View at Google Scholar · View at PubMed
  45. J. Tol and C. J. Punt, “Monoclonal antibodies in the treatment of metastatic colorectal cancer: a review,” Clinical Therapeutics, vol. 32, no. 3, pp. 437–453, 2010. View at Publisher · View at Google Scholar · View at PubMed
  46. D. Lal, J. A. Park, J. Marinaro et al., “Aflibercept exerts antivascular effects and enhances levels of anthracycline chemotherapy in vivo in human acute myeloid leukemia models,” Molecular Cancer Therapeutics, vol. 9, no. 10, pp. 2737–2751, 2010. View at Publisher · View at Google Scholar · View at PubMed
  47. T. Batchelor, D. G. Duda, E. di Tomaso et al., “Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma,” Journal of Clinical Oncology, vol. 28, no. 17, pp. 2817–2823, 2010. View at Publisher · View at Google Scholar · View at PubMed
  48. G. Goss, F. A. Shepherd, S. Laurie et al., “A phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer: a study of the National Cancer Institute of Canada Clinical Trials Group,” European Journal of Cancer, vol. 45, no. 5, pp. 782–788, 2009. View at Publisher · View at Google Scholar · View at PubMed
  49. B. Escudier, T. Eisen, W. M. Stadler et al., “Sorafenib in advanced clear-cell renal-cell carcinoma,” The New England Journal of Medicine, vol. 356, no. 2, pp. 125–134, 2007. View at Publisher · View at Google Scholar · View at PubMed
  50. L. Rimassa and A. Santoro, “Sorafenib therapy in advanced hepatocellular carcinoma: the SHARP trial,” Expert Review of Anticancer Therapy, vol. 9, no. 6, pp. 739–745, 2009. View at Publisher · View at Google Scholar · View at PubMed
  51. T. T. Shih, H. A. Hou, C. Y. Liu et al., “Bone marrow angiogenesis magnetic resonance imaging in patients with acute myeloid leukemia: peak enhancement ratio is an independent predictor for overall survival,” Blood, vol. 113, no. 14, pp. 3161–3167, 2009. View at Publisher · View at Google Scholar · View at PubMed
  52. B. B. Chen, C.-Y. Hsu, C.-W. Yu et al., “Dynamic contrast-enhanced MR imaging measurement of vertebral bone marrow perfusion may be indicator of outcome of acute myeloid leukemia patients in remission,” Radiology, vol. 258, no. 3, pp. 821–831, 2011. View at Publisher · View at Google Scholar · View at PubMed