Dietary Restriction Promotes Vessel Maturation in a Mouse Astrocytoma

Figure 2

Influence of dietary restriction on blood vessel maturation in the CT-2A astrocytoma. Confocal analysis of normal brain and CT-2A tumor tissue double stained for α-SMA in vascular smooth muscle cells (red) and Factor VIII in vascular endothelial cells (green). Results show that α-SMA is greater in the vessels of the DR-fed tumor than in the vessels of the AL-fed tumor (indicated by white arrow). A blood vessel of a normal brain is shown for comparison. All other conditions were as described in Section 2.