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Journal of Oncology
Volume 2012 (2012), Article ID 264039, 10 pages
doi:10.1155/2012/264039
Research Article
Dietary Restriction Promotes Vessel Maturation in a Mouse Astrocytoma
Biology Department, Boston College, Chestnut Hill, MA 0246, USA
Received 19 May 2011; Revised 22 September 2011; Accepted 25 September 2011
Academic Editor: Kalpna Gupta
Copyright © 2012 Ivan Urits et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- J. Folkman, “Tumor angiogenesis: therapeutic implications,” New England Journal of Medicine, vol. 285, no. 21, pp. 1182–1186, 1971. View at Scopus
- C. Rice and L. Eric Huang, “From antiangiogenesis to hypoxia: current research and future directions,” Cancer Management and Research, vol. 3, no. 1, pp. 9–16, 2010. View at Publisher · View at Google Scholar · View at PubMed
- D. Ribatti, “The inefficacy of antiangiogenic therapies,” Journal of Angiogenesis Research, vol. 2, no. 1, p. 27, 2010.
- I. F. Tannock, “The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour,” British Journal of Cancer, vol. 22, no. 2, pp. 258–273, 1968. View at Scopus
- J. Folkman, “What is the evidence that tumors are angiogenesis dependent?” Journal of the National Cancer Institute, vol. 82, no. 1, pp. 4–6, 1990. View at Scopus
- D. J. Hicklin and L. M. Ellis, “Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis,” Journal of Clinical Oncology, vol. 23, no. 5, pp. 1011–1027, 2005. View at Publisher · View at Google Scholar · View at PubMed
- K. J. Kim, B. Li, J. Winer et al., “Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo,” Nature, vol. 362, no. 6423, pp. 841–844, 1993. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. K. Jain, “Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy,” Nature Medicine, vol. 7, no. 9, pp. 987–989, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. L. Hayes, L. Y. Li, and M. E. Lippman, “Anti-vascular therapy: a new approach to cancer treatment,” Western Journal of Medicine, vol. 172, no. 1, pp. 39–42, 2000. View at Scopus
- D. Hanahan and J. Folkman, “Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis,” Cell, vol. 86, no. 3, pp. 353–364, 1996. View at Publisher · View at Google Scholar · View at Scopus
- G. Bergers and L. E. Benjamin, “Tumorigenesis and the angiogenic switch,” Nature Reviews Cancer, vol. 3, no. 6, pp. 401–410, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- G. Neufeld, T. Cohen, S. Gengrinovitch, and Z. Poltorak, “Vascular endothelial growth factor (VEGF) and its receptors,” FASEB Journal, vol. 13, no. 1, pp. 9–22, 1999. View at Scopus
- R. K. Jain, “Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy,” Science, vol. 307, no. 5706, pp. 58–62, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- K. De Bock, S. Cauwenberghs, and P. Carmeliet, “Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications,” Current Opinion in Genetics and Development, vol. 21, no. 1, pp. 73–79, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. M. Verbeek, I. Otte-Holler, P. Wesseling, D. J. Ruiter, and R. M. W. De Waal, “Induction of α-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-β1,” American Journal of Pathology, vol. 144, no. 2, pp. 372–382, 1994. View at Scopus
- S. Morikawa, P. Baluk, T. Kaidoh, A. Haskell, R. K. Jain, and D. M. McDonald, “Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors,” American Journal of Pathology, vol. 160, no. 3, pp. 985–1000, 2002. View at Scopus
- K. K. Hirschi, “PDGF, TGF-β, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate,” Journal of Cell Biology, vol. 141, no. 3, pp. 805–814, 1998. View at Publisher · View at Google Scholar · View at Scopus
- A. Antonelli-Orlidge, K. B. Saunders, S. R. Smith, and P. A. D'Amore, “An activated form of transforming growth factor β is produced by cocultures of endothelial cells and pericytes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 86, no. 12, pp. 4544–4548, 1989. View at Scopus
- R. O. Schlingemann, F. J. R. Rietveld, R. M. W. De Waal, S. Ferrone, and D. J. Ruiter, “Expression of the high molecular weight melanoma-associated antigen by pericytes during angiogenesis in tumors and in healing wounds,” American Journal of Pathology, vol. 136, no. 6, pp. 1393–1405, 1990. View at Scopus
- S. J. Lunt, N. Chaudary, and R. P. Hill, “The tumor microenvironment and metastatic disease,” Clinical and Experimental Metastasis, vol. 26, no. 1, pp. 19–34, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. Rapisarda and G. Melillo, “Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies,” Drug Resistance Updates, vol. 12, no. 3, pp. 74–80, 2009. View at Publisher · View at Google Scholar · View at PubMed
- S. Pennacchietti, P. Michieli, M. Galluzzo, M. Mazzone, S. Giordano, and P. M. Comoglio, “Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene,” Cancer Cell, vol. 3, no. 4, pp. 347–361, 2003. View at Publisher · View at Google Scholar · View at Scopus
- L. Terraneo, P. Bianciardi, A. Caretti, R. Ronchi, and M. Samaja, “Chronic systemic hypoxia promotes LNCaP prostate cancer growth in vivo,” Prostate, vol. 70, no. 11, pp. 1243–1254, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. I. Greenberg, D. J. Shields, S. G. Barillas et al., “A role for VEGF as a negative regulator of pericyte function and vessel maturation,” Nature, vol. 456, no. 7223, pp. 809–814, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. Abramovitch, H. Dafni, E. Smouha, L. E. Benjamin, and M. Neeman, “In vivo prediction of vascular susceptibility to vascular endothelial growth factor withdrawal: magnetic resonance imaging of C6 rat glioma in nude mice,” Cancer Research, vol. 59, no. 19, pp. 5012–5016, 1999.
- J. I. Greenberg and D. A. Cheresh, “VEGF as an inhibitor of tumor vessel maturation: implications for cancer therapy,” Expert Opinion on Biological Therapy, vol. 9, no. 11, pp. 1347–1356, 2009. View at Publisher · View at Google Scholar · View at PubMed
- H. Gerhardt and H. Semb, “Pericytes: gatekeepers in tumour cell metastasis?” Journal of Molecular Medicine, vol. 86, no. 2, pp. 135–144, 2008. View at Publisher · View at Google Scholar · View at PubMed
- I. Helfrich and D. Schadendorf, “Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma: one step forward for overcoming anti-angiogenic drug resistance?” Molecular Oncology, vol. 5, no. 2, pp. 137–149, 2011. View at Publisher · View at Google Scholar · View at PubMed
- H. J. Thompson, Z. Zhu, and W. Jiang, “Dietary energy restriction in breast cancer prevention,” Journal of Mammary Gland Biology and Neoplasia, vol. 8, no. 1, pp. 133–142, 2003. View at Publisher · View at Google Scholar
- S. Takano, Y. Yoshii, S. Kondo et al., “Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients,” Cancer Research, vol. 56, no. 9, pp. 2185–2190, 1996.
- D. Fukumura, R. Xavier, T. Sugiura et al., “Tumor induction of VEGF promoter activity in stromal cells,” Cell, vol. 94, no. 6, pp. 715–725, 1998. View at Publisher · View at Google Scholar
- A. K. Wong, M. Alfert, D. H. Castrillon et al., “Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 13, pp. 7481–7486, 2001. View at Publisher · View at Google Scholar · View at PubMed
- D. Mukhopadhyay and K. Datta, “Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors,” Seminars in Cancer Biology, vol. 14, no. 2, pp. 123–130, 2004. View at Publisher · View at Google Scholar · View at PubMed
- P. Mukherjee, A. V. Sotnikov, H. J. Mangian, J. R. Zhou, W. J. Visek, and S. K. Clinton, “Energy intake and prostate tumor growth, angiogenesis, and vascular endothelial growth factor expression,” Journal of the National Cancer Institute, vol. 91, no. 6, pp. 512–523, 1999.
- P. Mukherjee, L. E. Abate, and T. N. Seyfried, “Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors,” Clinical Cancer Research, vol. 10, no. 16, pp. 5622–5629, 2004. View at Publisher · View at Google Scholar · View at PubMed
- P. Mukherjee, M. M. El-Abbadi, J. L. Kasperzyk, M. K. Ranes, and T. N. Seyfried, “Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model,” British Journal of Cancer, vol. 86, no. 10, pp. 1615–1621, 2002. View at Publisher · View at Google Scholar · View at PubMed
- A. A. Powolny, S. Wang, P. S. Carlton, D. R. Hoot, and S. K. Clinton, “Interrelationships between dietary restriction, the IGF-I axis, and expression of vascular endothelial growth factor by prostate adenocarcinoma in rats,” Molecular Carcinogenesis, vol. 47, no. 6, pp. 458–465, 2008. View at Publisher · View at Google Scholar · View at PubMed
- J. Marsh, P. Mukherjee, and T. N. Seyfried, “Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/ tuberous sclerosis complex 2- deficient mouse astrocytoma,” Clinical Cancer Research, vol. 14, no. 23, pp. 7751–7762, 2008. View at Publisher · View at Google Scholar · View at PubMed
- A. Tannenbaum, “Nutrition and cancer,” in Physiopathology of Cancer, F. Homburge, Ed., pp. 517–562, New York, NY, USA, 1959.
- A. Tannenbaum, “The genesis and growth of tumors . II . Effects of caloric restriction per se,” Cancer Research, vol. 2, pp. 460–467, 1942.
- R. Weindruch, R. L. Walford, S. Fligiel, and D. Guthrie, “The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake,” Journal of Nutrition, vol. 116, no. 4, pp. 641–654, 1986.
- D. Kritchevsky, “Caloric restriction and experimental carcinogenesis,” Hybridoma and Hybridomics, vol. 21, no. 2, pp. 147–151, 2002.
- H. J. Flavin, A. Wieraszko, and T. N. Seyfried, “Enhanced aspartate release from hippocampal slices of epileptic (E1) mice,” Journal of Neurochemistry, vol. 56, no. 3, pp. 1007–1011, 1991.
- P. Workman, A. Balmain, J. A. Hickman et al., “UKCCCR guidelines for the welfare of animals in experimental neoplasia,” Laboratory Animals, vol. 22, no. 3, pp. 195–201, 1988.
- H. M. Zimmerman and H. Arnold, “Experimental brain tumors: II. Tumors produced with benzpyrene,” The American Journal of Pathology, vol. 19, no. 6, pp. 939–955, 1943.
- T. N. Seyfried, M. El-Abbadi, and M. L. Roy, “Ganglioside distribution in murine neural tumors,” Molecular and Chemical Neuropathology, vol. 17, no. 2, pp. 147–167, 1992.
- T. N. Seyfried, R. K. Yu, M. Saito, and M. Albert, “Ganglioside composition of an experimental mouse brain tumor,” Cancer Research, vol. 47, no. 13, pp. 3538–3542, 1987.
- M. K. Ranes, M. El-Abbadi, M. G. Manfredi, P. Mukherjee, F. M. Platt, and T. N. Seyfried, “N-butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours,” British Journal of Cancer, vol. 84, no. 8, pp. 1107–1114, 2001. View at Publisher · View at Google Scholar · View at PubMed
- L. B. Mahoney, C. A. Denny, and T. N. Seyfried, “Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans,” Lipids in Health and Disease, vol. 5, article 13, 2006. View at Publisher · View at Google Scholar · View at PubMed
- W. Zhou, P. Mukherjee, M. A. Kiebish, W. T. Markis, J. G. Mantis, and T. N. Seyfried, “The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer,” Nutrition and Metabolism, vol. 4, article 5, 2007. View at Publisher · View at Google Scholar · View at PubMed
- R. Weindruch and R. L. Walford, The Retardation of Agining and Disease by Dietary Restriction, Charles C Thomas, 1988.
- C. A. Denny, J. L. Kasperzyk, K. N. Gorham, R. T. Bronson, and T. N. Seyfried, “Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice,” Journal of Neuroscience Research, vol. 83, no. 6, pp. 1028–1038, 2006. View at Publisher · View at Google Scholar · View at PubMed
- H. J. Thompson, J. N. McGinley, N. S. Spoelstra, W. Jiang, Z. Zhu, and P. Wolfe, “Effect of dietary energy restriction on vascular density during mammary carcinogenesis,” Cancer Research, vol. 64, no. 16, pp. 5643–5650, 2004. View at Publisher · View at Google Scholar · View at PubMed
- P. Carmeliet, “Mechanisms of angiogenesis and arteriogenesis,” Nature Medicine, vol. 6, no. 4, pp. 389–395, 2000. View at Publisher · View at Google Scholar · View at PubMed
- P. Carmeliet and R. K. Jain, “Angiogenesis in cancer and other diseases,” Nature, vol. 407, no. 6801, pp. 249–257, 2000. View at Publisher · View at Google Scholar · View at PubMed
- P. Carmeliet, “VEGF as a key mediator of angiogenesis in cancer,” Oncology, vol. 69, supplement 3, no. 3, pp. 4–10, 2005. View at Publisher · View at Google Scholar · View at PubMed
- R. K. Jain, “Molecular regulation of vessel maturation,” Nature Medicine, vol. 9, no. 6, pp. 685–693, 2003. View at Publisher · View at Google Scholar · View at PubMed
- R. T. Tong, Y. Boucher, S. V. Kozin, F. Winkler, D. J. Hicklin, and R. K. Jain, “Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors,” Cancer Research, vol. 64, no. 11, pp. 3731–3736, 2004. View at Publisher · View at Google Scholar · View at PubMed
- C. A. Denny, K. A. Heinecke, Y. P. Kim et al., “Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice,” Journal of Neurochemistry, vol. 113, no. 6, pp. 1525–1535, 2010. View at Publisher · View at Google Scholar · View at PubMed
- A. D. Norden, J. Drappatz, and P. Y. Wen, “Novel anti-angiogenic therapies for malignant gliomas,” The Lancet Neurology, vol. 7, no. 12, pp. 1152–1160, 2008. View at Publisher · View at Google Scholar · View at PubMed
- N. Ferrara and R. S. Kerbel, “Angiogenesis as a therapeutic target,” Nature, vol. 438, no. 7070, pp. 967–974, 2005. View at Publisher · View at Google Scholar · View at PubMed
- S. S. Lakka and J. S. Rao, “Antiangiogenic therapy in brain tumors,” Expert Review of Neurotherapeutics, vol. 8, no. 10, pp. 1457–1473, 2008. View at Publisher · View at Google Scholar · View at PubMed