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Figure 3: Imaging of early events of colorectal liver metastasis by intravital TPLSM. (a) Normal liver. (b) Arrest of a tumor cell in the hepatic sinusoid (2 hours after inoculation). (c) Tumor-cell-induced platelet aggregation (white arrows, 2 hours after inoculation). (d) Phagocytosis by a Kupffer cell (24 hours after inoculation). (e) Phagocytosis by a Kupffer cell at different depth. (f) Extravasation of a tumor cell (24 hours after inoculation) (bar, 50 μm).