About this Journal Submit a Manuscript Table of Contents
Journal of Oncology
Volume 2012 (2012), Article ID 265487, 8 pages
http://dx.doi.org/10.1155/2012/265487
Research Article

In Vivo Time-Course Imaging of Tumor Angiogenesis in Colorectal Liver Metastases in the Same Living Mice Using Two-Photon Laser Scanning Microscopy

1Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
2Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan

Received 27 May 2011; Revised 19 August 2011; Accepted 30 August 2011

Academic Editor: Sundaram Ramakrishnan

Copyright © 2012 Koji Tanaka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Leite de Oliveira, A. Hamm, and M. Mazzone, “Growing tumor vessels: more than one way to skin a cat—implications for angiogenesis targeted cancer therapies,” Molecular Aspects of Medicine, vol. 32, no. 2, pp. 71–87, 2011. View at Publisher · View at Google Scholar
  2. R. Oklu, T. G. Walker, S. Wicky, and R. Hesketh, “Angiogenesis and current antiangiogenic strategies for the treatment of cancer,” Journal of Vascular and Interventional Radiology, vol. 21, no. 12, pp. 1791–1805, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. D. J. Gallagher and N. Kemeny, “Metastatic colorectal cancer: from improved survival to potential cure,” Oncology, vol. 78, no. 3-4, pp. 237–248, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Cunningham, W. Atkin, H. J. Lenz et al., “Colorectal cancer,” The Lancet, vol. 375, no. 9719, pp. 1030–1047, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Platell, S. Ng, A. O'Bichere, and N. Tebbutt, “Changing management and survival in patients with stage IV colorectal cancer,” Diseases of the Colon and Rectum, vol. 54, no. 2, pp. 214–219, 2011. View at Publisher · View at Google Scholar
  6. Y. Kienast, L. Von Baumgarten, M. Fuhrmann et al., “Real-time imaging reveals the single steps of brain metastasis formation,” Nature Medicine, vol. 16, no. 1, pp. 116–122, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. B. J. Vakoc, R. M. Lanning, J. A. Tyrrell et al., “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nature Medicine, vol. 15, no. 10, pp. 1219–1223, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Fukumura, D. G. Duda, L. L. Munn, and R. K. Jain, “Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models,” Microcirculation, vol. 17, no. 3, pp. 206–225, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Toiyama, A. Mizoguchi, Y. Okugawa et al., “Intravital imaging of DSS-induced cecal mucosal damage in GFP-transgenic mice using two-photon microscopy,” Journal of Gastroenterology, vol. 45, no. 5, pp. 544–553, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Kawano, T. Kogure, Y. Abe, H. Mizuno, and A. Miyawaki, “Two-photon dual-color imaging using fluorescent proteins,” Nature Methods, vol. 5, no. 5, pp. 373–374, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Erpenbeck and M. P. Schön, “Deadly allies: the fatal interplay between platelets and metastasizing cancer cells,” Blood, vol. 115, no. 17, pp. 3427–3436, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Sabrkhany, A. W. Griffioen, and M. G. A. oude Egbrink, “The role of blood platelets in tumor angiogenesis,” Biochimica et Biophysica Acta, vol. 1815, no. 2, pp. 189–196, 2011. View at Publisher · View at Google Scholar
  13. F. Winkler, Y. Kienast, M. Fuhrmann et al., “Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis,” Glia, vol. 57, no. 12, pp. 1306–1315, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. C. T. Farrar, W. S. Kamoun, C. D. Ley et al., “In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model,” Neuro-Oncology, vol. 12, no. 4, pp. 341–350, 2010. View at Scopus
  15. J. T. Erler and V. M. Weaver, “Three-dimensional context regulation of metastasis,” Clinical and Experimental Metastasis, vol. 26, no. 1, pp. 35–49, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. E. M. Bridges and A. L. Harris, “The angiogenic process as a therapeutic target in cancer,” Biochemical Pharmacology, vol. 81, no. 10, pp. 1183–1191, 2011. View at Publisher · View at Google Scholar