In Vivo Time-Course Imaging of Tumor Angiogenesis in Colorectal Liver Metastases in the Same Living Mice Using Two-Photon Laser Scanning Microscopy

Table 1

Early events of colorectal liver metastasis in the portal route model.

Early event	RFP-HT29 cells in GFP nude mice
Tumor-cell arrest/adhesion	20/20* (100%)^#
Tumor-cell-induced platelet aggregation	15/20 (75%)
Extravasation from hepatic sinusoids	1/20 (5%)
Phagocytosis by Kupffer cells	2/20 (10%)

*Number of mice having the indicated phenomenon/number of mice inoculated with the indicated cells.
^#Percentage.