Role of Protein Biomarkers in the Detection of High-Grade Disease in Cervical Cancer Screening Programs
Figure 3
Biomarker expression in cervical intraepithelial neoplasia. The proliferative compartment progressively expands with histological grade, and this is paralleled by the appearance of immunostaining for Ki-67, p16INK4a, and BD ProEx C in more superficial epithelial layers, with the majority of the epithelium staining in high-grade squamous intraepithelial lesions. For Cytoactiv HPV L1, higher expression is found in low-grade lesions, with a loss of L1 protein often observed in high-grade lesions (L1 images courtesy of Dr. Ralf Hilfrich).
