Rapid Stereomicroscopic Imaging of HER2 Overexpression in Ex Vivo Breast Tissue Using Topically Applied Silica-Based Gold Nanoshells
Figure 5
(a) Stereomicroscopic images of HER2-overexpressing breast tissue (with and without neoadjuvant chemotherapy) and normal breast tissue incubated with HER2-targeted nanoshells for 5 minutes at 37°C after contrast enhancement. Magnification at 2x; scale bar = 2.5 mm. Arrows represent nanoshells. (b) Respective reflectance confocal microscopy images of tissue samples from (a). Power = 0.4 mW and scale bar = 75 μm. Respective (c) HER2 immunohistochemistry and (d) H&E results taken under brightfield microscopy under 20x magnification. Scale bar = 0.35 mm.
