Clinical Study

Age of 40 Years or Younger Is an Independent Risk Factor for Locoregional Failure in Early Breast Cancer: A Single-Institutional Analysis in Saudi Arabia

Table 1

Comparison of clinical and pathological characteristics of patients ≤40 years and >40 years of age at diagnosis.

CharacteristicAge (years) 𝑃 value
≤40>40
𝑛 % 𝑛 %

Body mass index
 <251425.5138.2≤0.05
 25–291425.53622.8n.s.
 ≥301425.56943.7≤0.05
 Unknown1323.64025.3n.s.

Menopausal status
 Premenopausal5498.27547.5≤0.05
 Postmenopausal11.88652.5≤0.05

Family history
 No cancers in blood relatives2341.85736.1n.s.
 Other than breast cancer in at least one blood relative11.842.5n.s.
 Other than breast cancer in at least one first degree relative610.985.1n.s.
 Breast cancer or ovarian cancer in at least one blood relative47.3138.2n.s.
 Breast cancer or ovarian cancer in at least one first degree relative23.61912.0n.s.
 Unknown1934.55736.1n.s.

Histology
 Invasive ductal4989.114390.5n.s.
 Invasive lobular23.6127.6n.s.
 DCIS35.531.9n.s.
 LCIS11.800n.a.

T stage
 Tis47.331.9n.s.
 T011.800.0n.a.
 T11629.15534.8n.s.
 T22240.05937.3n.s.
 T347.32717.1n.s.
 T4610.9106.3n.s.
 Tx23.642.5n.s.

N stage
 N01832.75937.3n.s.
 N11730.94629.1n.s.
 N21120.02314.6n.s.
 N3610.92616.5n.s.
 Nx35.542.5n.s.

Stage
 047.331.9n.s.
 I610.93522.2n.s.
 II1934.55635.4n.s.
 III2341.85937.3n.s.
 Unknown35.553.2n.s.
Grading
 G123.6148.9n.s.
 G21730.94729.7n.s.
 G32240.07144.9n.s.
 Gx1425.52616.5n.s.

Lymphovascular invasion (LV)
 LV01730.95031.6n.s.
 LV11527.35333.5n.s.
 Unknown2341.85534.8n.s.

Type of surgery
 Breast conserving surgery2240.07044.3n.s.
 Mastectomy3360.08855.7n.s.

Neoadjuvant chemotherapy
 No4683.613786.7n.s.
 Yes916.42113.3n.s.

Residual tumor (R) status
 R04174.512277.2n.s.
 R135.5127.6n.s.
 Unknown1120.02415.2n.s.

Estrogen receptor (ER) status
 ER negative1730.94327.2n.s.
 ER positive3360.010667.1n.s.
 Unknown59.195.7n.s.

Progesterone receptor (PR) status
 PR negative2341.85232.9n.s.
 PR positive2749.19761.4n.s.
 Unknown59.195.7n.s.

Her2neu status
 Her2neu negative3360.011572.8n.s.
 Her2neu positive1221.82918.4n.s.
 Unknown1018.2148.9n.s.

Tumor subtype
 Luminal A2036.49459.5≤0.05
 Luminal B916.41710.8n.s.
 Her2 overexpressing35.5127.6n.s.
 Triple negative1425.52113.3≤0.05
 Unknown916.4148.9n.s.