Age of 40 Years or Younger Is an Independent Risk Factor for Locoregional Failure in Early Breast Cancer: A Single-Institutional Analysis in Saudi Arabia

Table 2

Results of the Kaplan-Meier analysis.

Factor	𝑛	2-year locoregional failure-free survival	95% CI	𝑃 value
Age				0.005
Age ≤40	54	0.86	0.75–0.98
Age >40	158	0.98	0.95–1.00
Menopausal status				0.52
Premenopausal	129	0.99	0.97–1.00
Postmenopausal	84	0.97	0.91–1.00
BMI				0.31
BMI <30	72	0.95	0.88–1.00
BMI ≥30	83	0.97	0.92–1.00
T stage				0.03
Tis, T0–2	159	0.98	0.95–1.00
T3-4	47	0.89	0.78–1.00
N stage				0.13
N0	77	1.00	1.00-1.00
N+	128	0.94	0.88–1.00
Grading				0.27
G1-2	80	1.00	1.00-1.00
G3	93	0.93	0.86–1.00
Tumor subtype				0.03
Luminal A	75	0.91	0.83–0.99
Others*	114	0.99	0.97–1.00
Lymphovascular status				0.02
LV0	67	1.00	1.00-1.00
LV1	68	0.90	0.79–1.00
Type of surgery				0.59
Mastectomy	121	0.96	0.91–1.00
BCS	91	0.97	0.92–1.00
Residual tumor status				0.56
R0	163	0.97	0.93–1.00
R1	15	1.00	1.00-1.00

Abbreviations. BMI: body mass index; *: luminal B, Her2 overexpressing, or triple negative; BCS: breast conserving surgery; CI: confidence interval.