Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors

Table 4

Postoperative radiation therapy: univariate analysis of overall survival, locoregional control, and metastasis-free survival.

Factor	Overall survival		Locoregional failure		Metastasis
	5y-survival	𝑃	5y-CIF	𝑃	5y-CIF	𝑃
Gender
Female	0.89 (95% CI 0.75–1.03)		0.53 (95% CI 0.10–0.85)		0.11 (95% CI 0.02–0.29)
Male	0.66 (95% CI 0.54–0.77)	0.17	0.33 (95% CI 0.23–0.44)	0.56	0.21 (95% CI 0.14–0.30)	0.27
Age (years)
≤56	0.72 (95% CI 0.60–0.84)		0.29 (95% CI 0.17–0.41)		0.21 (95% CI 0.12–0.31)
>56	0.65 (95% CI 0.47–0.82)	0.87	0.45 (95% CI 0.27–0.61)	0.10	0.19 (95% CI 0.09–0.31)	0.85
Hemoglobin level pre-RT (g/dL)
≤12	0.64 (95% CI 0.46–0.83)		0.41 (95% CI 0.20–0.61)		0.17 (95% CI 0.07–0.31)
>12	0.69 (95% CI 0.55–0.84)	0.72	0.27 (95% CI 0.16–0.40)	0.42	0.23 (95% CI 0.13–0.35)	0.45
Tumor site
Oropharynx	0.72 (95% CI 0.58–0.86)		0.44 (95% CI 0.27–0.59)		0.14 (95% CI 0.07–0.23)
Hypopharynx	0.65 (95% CI 0.51–0.80)	0.35	0.28 (95% CI 0.16–0.41)	0.46	0.27 (95% CI 0.15–0.40)	0.30
T-Classification
1, 2	0.69 (95% CI 0.54–0.83)		0.34 (95% CI 0.20–0.49)		0.19 (95% CI 0.11–0.30)
3, 4	0.70 (95% CI 0.56–0.83)	0.80	0.37 (95% CI 0.23–0.52)	0.60	0.20 (95% CI 0.11–0.32)	0.94
N-Classification
0, 1	0.72 (95% CI 0.54–0.89)		0.28 (95% CI 0.12–0.48)		0.10 (95% CI 0.04–0.21)
2, 3	0.68 (95% CI 0.55–0.80)	0.24	0.40 (95% CI 0.27–0.53)	0.06	0.26 (95% CI 0.16–0.36)	0.03
R-Classification
0	0.68 (95% CI 0.56–0.80)		0.37 (95% CI 0.23–0.50)		0.21 (95% CI 0.11–0.31)
1, 2	0.69 (95% CI 0.59–0.79)	0.95	0.37 (95% CI 0.16–0.58)	0.81	0.20 (95% CI 0.07–0.33)	0.80
Total tumor volume (cm^3)
≤21.2	0.65 (95% CI 0.47–0.82)		0.23 (95% CI 0.09–0.37)		0.17 (95% CI 0.07–0.27)
>21.2	0.61 (95% CI 0.45–0.76)	0.13	0.44 (95% CI 0.27–0.60)	0.04	0.26 (95% CI 0.14–0.39)	0.25
RT interruptions >5 days
Yes	0.66 (95% CI 0.45–0.87)		0.51 (95% CI 0.26–0.72)		0.25 (95% CI 0.10–0.44)
No	0.70 (95% CI 0.57–0.82)	0.22	0.27 (95% CI 0.17–0.39)	0.10	0.18 (95% CI 0.11–0.27)	0.26
Interval surgery-RT >32 days
Yes	0.66 (95% CI 0.51–0.80)	0.50	0.45 (95% CI 0.28–0.60)	0.40	0.20 (95% CI 0.11–0.32)	0.79
No	0.70 (95% CI 0.54–0.85)		0.27 (95% CI 0.15–0.40)		0.20 (95% CI 0.11–0.32)

RT: radiation therapy; CIF: cumulative incidence function; 𝑃: 𝑃 value.