Current and Emerging Therapeutic Options in Adrenocortical Cancer Treatment

Table 1

Staging systems of adrenal cortical carcinoma (ACC) according to the criteria of the Union Internationale Contre Cancer (UICC) 2004 and the European Network for the Study of Adrenal Tumors (ENSAT) 2008.

Stage	UICC/WHO 2004	ENSAT 2008
I	T1, N0, M0	T1, N0, M0
II	T2, N0, M0	T2, N0, M0
III	T1-2, N1, M0; T3, N0, M0	T1-2, N1, M0; T3-4, N0-1, M0
IV	T1–4, N0-1, M1; T3, N1, M0; T4, N0-1, M0	T1–4, N0-1, M1

T1: tumor ≤5 cm; T2: tumor >5 cm; T3: tumor infiltration into surrounding tissue; T4: tumor invasion into adjacent organs or venous tumor thrombosis; N0: no positive lymph nodes; N1: positive lymph node(s); M0: no distant metastasis; M1: distant metastasis.