N-Acetyltransferase 1 (NAT1) Genotype: A Risk Factor for Urinary Bladder Cancer in a Lebanese Population
Table 4
Multivariate logistic regression analysis testing for independent effects of suspected risk factors, as well as for a potential gene-environment interaction.The used best-fit model is based on the following variables in the crude model: income, family history, passive smoking at the work place, occupational exposure to combustion fumes, previous history of prostate-related symptoms, and history of urinary tract infections.
Variable
Testing for independent effect
Testing for potential gene-environment interaction
NAT1*14A
NAT1*10
Adjusted OR (CI)
Adjusted OR (CI)
Adjusted OR(CI)
Noneadjusted OR (CI)
Income (reference 500 $/month)
500–1000
2.14 (0.4–11.4)
1.06 (0.05–21.2)
5.87 (0.26–133.2)
14.59 (0.04–5318.5)
>1000
7.45 (0.91–61.2)
2.18 (0.04–114.1)
10.81 (0.085–1369.54)
11.45 (0.098–1334.9)
Smoking
1.02* (1.01–1.04)
1.024* (0.991–1.06)
1.017 (0.99–1.04)
1.039 (0.98–1.104)
Occupational exposure to combustion fumes (reference none)