Table 1: Association between HPV1 E6 and/or E7 status with head and neck cancer risk factors.

Risk FactorsOral cavity cases ( 𝑁 = 1 7 0 )Oropharynx cases ( 𝑁 = 7 4 )Controls ( 𝑁 = 4 2 8 )
HPV E6/E7+
N (%)
HPV E6/E7−
N (%)
Adjusted
𝑃 value
HPV E6/E7+
N (%)
HPV E6/E7−
N (%)
Adjusted
𝑃 value
HPV E6/E+
N (%)
HPV E6/E7−
N (%)
Adjusted 𝑃 value

HPV prevalence16 (9.4)154 (90.6)47 (63.5)27 (36.5)31 (7.2)397 (92.8)

Age3Oral cavity positive versus oropharyngeal positive: 𝑃 value = 0.01; oral cavity negative versus oropharyngeal negative: 𝑃 value = 0.33
 Mean64.7 (3.6)61.2 (1.5)0.3554.5 (2.1)58.2 (2.7)0.2856.8 (2.7)58.1 (0.7)0.63
 Range45–8621–9336–8229–8518–7722–93
5 5 6 (37.5)55 (35.7)0.9629 (61.7)11 (40.7)0.0514 (45.2)166 (41.8)0.83
 >5510 (62.5)99 (64.3)18 (38.3)16 (59.3)17 (54.8)231 (58.2)
Gender
 Male14 (87.5)79 (51.3)0.0340 (85.1)19 (70.4)0.0421 (67.7)247 (62.2)0.10
 Female2 (12.5)75 (48.7)7 (14.9)8 (29.6)10 (32.3)150 (37.8)
Education3
 <125 (31.3)34 (22.4)0.585 (10.9)11 (40.7)0.072 (6.5)52 (13.1)0.87
 12–159 (56.3)87 (57.2)0.5032 (69.6)10 (37.0)0.5118 (58.1)226 (57.1)0.61
 ≥162 (12.5)31 (20.4)Ref9 (19.6)6 (22.2)Ref11 (35.5)118 (29.8)Ref
Tobacco4
 Never3 (18.8)54 (35.3)Ref8 (17.4)2 (7.4)Ref10 (34.5)150 (37.9)Ref
 >0.0–303 (18.8)41 (26.8)0.5919 (41.3)6 (22.2)0.8515 (51.7)127 (32.1)0.24
 >3010 (62.5)58 (37.9)9.9419 (41.3)19 (70.4)0.374 (13.8)119 (30.1)0.24
Alcohol5
 Never3 (18.8)57 (37.3)Ref6 (13.0)2 (7.4)Ref14 (45.2)170 (43.0)Ref
 1–215 (31.3)54 (35.3)0.9227 (58.7)10 (37.0)0.6715 (48.4)166 (42.0)0.95
 >218 (50.0)42 (27.5)0.6413 (28.3)15 (55.6)0.142 (6.5)59 (14.9)0.30
Number of Partners
 0-16 (42.9)60 (42.9)Ref3 (7.1)4 (16.7)Ref10 (34.5)122 (32.3)Ref
 2–105 (35.7)59 (42.1)0.5623 (54.8)13 (54.2)0.5516 (55.2)186 (49.2)0.64
 ≥113 (21.4)21 (15.0)0.6616 (38.1)7 (29.2)0.703 (10.3)70 (18.5)0.21
Oral-genital sex
 Yes3 (37.5)39 (49.4)0.8324 (92.3)8 (50.0)0.0216 (51.6)184 (53.8)0.27
 No5 (62.5)40 (50.6)2 (7.7)8 (50.0)15 (48.4)158 (46.2)
Stage
 I/II8 (50.0)58 (39.5)Ref3 (6.8)5 (19.2)Ref
 III/IV8 (50.0)89 (60.5)0.3041 (93.2)21 (80.8)0.19
Grade
 Poor/undifferentiated5 (33.3)23 (16.2)0.1325 (55.6)3 (12.5)0.004
 well/moderate10 (66.7)119 (83.8)Ref20 (44.4)21 (87.5)Ref
Nodal status
 Yes7 (43.7)54 (36.0)0.8742 (89.4)20 (74.1)0.07
 No9 (56.3)96 (64.0)Ref5 (10.6)7 (25.9)Ref

1Positive versus negative for HPV-16 or HPV-18 or HPV-33 E6 and/or E7 status; 2adjusted for age, gender, tobacco, and alcohol; 3years; 4pack-years; 5drinks/week.