Table 2: Site-specific head and neck cancer associated with tobacco, alcohol, and HPV E6/E7 status.1

CasesControlsOral Cavity versus controlsOropharynx versus controls
Oral cavity ( 𝑁 = 1 7 0 )Oropharynx ( 𝑁 = 7 4 )( 𝑁 = 4 2 8 )OR2 (95% CI)OR2 (95% CI)
CharacteristicN (%)N (%)N (%)

Tobacco
 Never57 (33.7)10 (13.7)160 (37.7)1.01.0
 ≤3044 (26.0)25 (34.2)142 (33.4)0.9 (0.5–1.4)2.1 (0.9–5.2)
 >3068 (40.2)38 (52.1)123 (28.9)1.5 (0.9–2.4)5.6 (2.3–13.7)
Alcohol
 Never60 (35.5)8 (11.0)184 (43.2)1.01.0
 ≤2159 (34.9)37 (50.7)181 (42.5)1.1 (0.7–1.8)4.3 (1.7–10.4)
 >2150 (29.6)28 (38.4)61 (14.3)3.6 (2.1–6.2)11.7 (4.2–32.7)
Tobacco/alcohol
 Never/never42 (25.0)3 (4.1)100 (23.6)1.01.0
 ≤30/≤2123 (13.7)14 (19.2)72 (17.0)1.0 (0.5–1.8)5.2 (1.2–21.7)
 ≤30/>2110 (6.0)8 (11.0)26 (6.1)1.4 (0.6–3.5)15.9 (3.2–80.2)
 >30/≤2122 (13.1)17 (23.3)55 (13.0)1.3 (0.6–2.4)16.6 (3.9–71.4)
 >30/>2139 (23.2)19 (26.0)29 (6.9)5.2 (2.6–10.5)34.6 (7.5–158.8)
HPV E6/E7 status1
 Positive16 (9.4)47 (63.5)31 (7.2)1.7 (0.9–3.3)24.3 (12.9–45.8)
 Negative3154 (90.6)27 (36.5)397 (92.8)1.01.0

1Percentages based on available data; 2odds ratio adjusted by age (continuous), gender, HPV status, tobacco, and alcohol; 3HPV E6/E7 negative status for all types, E6/E7 positive status for HPV-16, -18, and/or -33.