Table 3: Site-specific head and neck cancer stratified by HPV E6/E7, tobacco, and alcohol status.1

CasesControlsOral cavity versus controlsOropharynx versus controls
Oral cavityOropharynx OR (95% CI) OR (95% CI)
HPV E6/E72Risk factor 𝑁 = 1 7 0 (%) 𝑁 = 7 4 (%) 𝑁 = 4 2 8 (%)

 Tobacco3
 Negative  Never54 (32.0)2 (2.7)150 (35.3)1.01.0
  ≤3041 (24.3)6 (8.2)127 (29.9)0.9 (0.6–1.5)3.2 (0.6–16.6)
  >3058 (34.3)19 (26.0)119 (28.0)1.4 (0.8–2.3)11.0 (2.4–51.7)
  test for trend 𝑃 value0.19<0.0001
 Positive  Never3 (1.8)8 (11.0)10 (2.4)1.01.0
  ≤303 (1.8)19 (26.0)15 (3.5)0.3 (0.03–2.4)1.4 (0.4–4.9)
  >3010 (5.9)19 (26.0)4 (0.9)3.5 (0.5–26.9)4.7 (1.03–21.7)
  test for trend 𝑃 value0.0080.01
 Alcohol4
 Negative  Never57 (33.7)2 (2.7)170 (39.9)1.01.0
  ≤2154 (32.0)10 (13.7)166 (39.0)1.1 (0.7–1.8)5.4 (1.1–25.7)
  >2142 (24.8)15 (20.6)59 (13.9)3.1 (1.7–5.5)24.3 (4.9–121.3)
test for trend 𝑃 value0.009<0.0001
 Positive  Never3 (1.8)6 (8.2)14 (3.3)1.01.0
  ≤215 (3.0)27 (37.0)15 (3.5)1.2 (0.2–7.3)4.1 (1.2–14.7)
  >218 (4.7)13 (17.8)2 (0.5)9.8 (0.9–106.9)8.5 (1.2–60.2)
  test for trend 𝑃 value0.0020.001
Tobacco/alcohol5
 Negative  Never/never40 (23.8)1 (1.4)93 (22.0)1.01.0
  ≤30/≤2121 (12.5)1 (1.4)63 (14.9)1.0 (0.5–1.9)1.9 (0.1–31.1)
  ≤30/>2110 (6.0)4 (5.5)24 (5.7)1.5 (0.6–3.6)22.8 (2.2-235.2)
  >30/≤2120 (11.9)8 (11.0)53 (12.5)1.2 (0.6–2.3)18.7 (2.2–160.8)
  >30/>2131 (18.4)11 (15.1)29 (6.7)4.0 (2.0–8.3)56.3 (6.2–512.7)
  test for trend 𝑃 value0.07<0.0001
 Positive  Never/never2 (1.2)2 (2.7)7 (1.7)1.01.0
  ≤30/≤212 (1.2)13 (17.8)9 (2.1)0.7 (0.04–12.0)8.9 (0.96–82.9)7
  ≤30/>210 (0.0)4 (5.5)2 (0.5)0.6 (0.02–17.2) 613.7 (0.8–227.9)
  >30/≤212 (1.2)9 (12.3)2 (0.5)2.6 (0.1–67.4)29.3 (2.1–408.7)7
  >30/>218 (4.8)8 (11.0)0 (0.0)55.0 (0.8–3651.0)6,718.3 (0.5–627.2)6,7
  test for trend 𝑃 -value0.0080.001

1Percentages based on available data; 2HPV E6/E7 seronegative for HPV-16, -18, and/or -33; HPV E6/E7 seropositive for HPV-16, -18, and/or -33; 3adjusted for age (continuous), gender, and average drinks/week (continuous); 4adjusted for age (continuous), gender, and tobacco pack-years (continuous); 5adjusted for age (continuous) and gender, all never groups combined with never/never as reference group; 6Logit estimator, 0.5 is added to zero cells; 7CMH 𝑃 -value < 0.049.